Because of its broad-spectrum activity against a variety of intestinal pathogens, there has been interest in evaluating nitazoxanide as a potential agent for public health control. In this Editorial, Peter J. Hotez discusses the possibility of adding nitazoxanide to current regimens used for WHO preventive chemotherapy initiatives as a means to broaden coverage against intestinal protozoa and possibly other pathogens.
For many years, authors have argued that the effects of chemotherapy on the control of STH and schistosomiasis can only be sustainable if integrated with improvements in health promotion, hygiene, and sanitation. In this Policy Platform, Suzy J. Campbell and colleagues discuss the importance of Water, Sanitation, and Hygiene (WASH) for the control of STH and schistosomiasis.
The rapid expansion of mobile networks globally, coupled with the decreasing cost of mobile equipment, is allowing global health programs increasingly to utilize mobile- and cloud-based technology in their efforts to target important challenges to public health. The present report, conducted by Alex Pavluck and colleagues, describes a second-generation, more efficient, cloud-based, smartphone-based system and the key elements that lead to its greater efficiency.
Image Credit: Flickr, Juhan Sonin
In leprosy, classic diagnostic tools based on bacillary counts and histopathology have been facing hurdles, especially in distinguishing latent infection from active disease and diagnosing paucibacillary clinical forms. In this Review, Alejandra Nóbrega Martinez and colleagues discuss recent results indicating that quantitative PCR (qPCR) is a key technique due to its higher sensitivity and specificity.
Image Credit: Flickr, University of Michigan School of Natural Resources & Environment
In this research article, Marcio R. T. Nunes and colleagues investigated the spatial dynamics of DENV-1, DENV-2 and DENV-3 in Brazil by applying a statistical framework to complete genome sequences. Their analysis indicates that aerial transportation is a more important determinant of viral dispersal than Aedes aegypti infestation rates or geographical distance.
Image Credit: Flickr, János Tamás
In this 24 month vaccine trial, Hamid Daneshvar and colleagues vaccinated dogs with gentamicin-attenuated line of Leishmania infantum. They found that one out of 46 (2.2%) vaccinated dogs and 9 out of 31 (29%) unvaccinated dogs developed clinical signs of disease. These results suggest that gentamicin-attenuated L. infantum induced a significant and strong protective effect against canine visceral leishmaniosis in the endemic area.
Image Credit: Flickr, Hamed Saber
The El Niño Southern Oscillation is a major ocean–atmosphere phenomenon that strongly contributes to the timing and intensity of rainfall in the tropical Pacific islands and beyond. As a consequence, it also has a major effect on the number of cases of leptospirosis. By incorporating oceanographic parameters in models, Daniel Weinberger and colleagues were able to predict leptospirosis outbreaks in New Caledonia 4 months in advance.
Image Credit: Flickr, Ingrid Taylar