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Research Article

Molecular Evidence for a Functional Ecdysone Signaling System in Brugia malayi

  • George Tzertzinis mail,

    tzertzinis@neb.com

    Affiliation: New England Biolabs, Ipswich, Massachusetts, United States of America

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  • Ana L. Egaña,

    Affiliation: New England Biolabs, Ipswich, Massachusetts, United States of America

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  • Subba Reddy Palli,

    Affiliation: Department of Entomology, University of Kentucky, Lexington, Kentucky, United States of America

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  • Marc Robinson-Rechavi,

    Affiliation: Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland

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  • Chris R. Gissendanner,

    Affiliation: New England Biolabs, Ipswich, Massachusetts, United States of America

    Current address: Department of Biology, University of Louisiana at Monroe, Monroe, Louisiana 71209, United States of America

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  • Canhui Liu,

    Affiliation: Global Health Infectious Disease Research Program, College of Public Health, University of South Florida, Tampa, Florida, United States of America

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  • Thomas R. Unnasch,

    Affiliation: Global Health Infectious Disease Research Program, College of Public Health, University of South Florida, Tampa, Florida, United States of America

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  • Claude V. Maina

    Affiliation: New England Biolabs, Ipswich, Massachusetts, United States of America

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  • Published: March 09, 2010
  • DOI: 10.1371/journal.pntd.0000625

Reader Comments (1)

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The nematode EcR era begins...

Posted by LloydG on 11 Mar 2010 at 00:08 GMT

Very interesting work, especially the functional data.

Feb/Mar 2010 seems to have ushered in the era of the nematode EcR. Four papers have appeared over the past four weeks, each describing an EcR ortholog (and in some cases, the RXR as well) from a different nematode species – two from Clade III, and two from Clade V. In addition to this paper, I am aware of:

Parihar et al. (2010) The genome of the nematode Pristionchus pacificus encodes putative homologs of RXR/Usp and EcR. Gen. Comp. Endocrinol. (in press). doi:10.1016/j.ygcen.2010.02.005

Shea et al. (2010) An EcR homolog from the filarial parasite, Dirofilaria immitis requires a ligand-activated partner for transactivation. Mol. Biochem. Parasitol., in press. doi:10.1016/j.molbiopara.2010.02.002

Graham et al. (2010) An ortholog of the ecdysone receptor protein (EcR) from the parasitic nematode Haemonchus contortus. Mol. Biochem. Parasitol., in press. Pre-publication article at http://tinyurl.com/HcEcR, doi:10.1016/j.molbiopara.2010.03.003 (not yet live).

No competing interests declared.

RE: The nematode EcR era begins...

LloydG replied to LloydG on 11 Mar 2010 at 00:16 GMT

Sorry, the current URL for that last paper should be http://tinyurl.com/HcEcR (no comma).

No competing interests declared.