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Research Article

Resolution of Praziquantel

  • Michael Woelfle,

    Affiliation: School of Chemistry, The University of Sydney, Sydney, New South Wales, Australia

    X
  • Jean-Paul Seerden,

    Affiliation: Syncom B.V., Groningen, The Netherlands

    X
  • Jesse de Gooijer,

    Affiliation: Syncom B.V., Groningen, The Netherlands

    X
  • Kees Pouwer,

    Affiliation: Syncom B.V., Groningen, The Netherlands

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  • Piero Olliaro,

    Affiliation: UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), World Health Organization, Geneva, Switzerland

    X
  • Matthew H. Todd mail

    matthew.todd@sydney.edu.au

    Affiliation: School of Chemistry, The University of Sydney, Sydney, New South Wales, Australia

    X
  • Published: September 20, 2011
  • DOI: 10.1371/journal.pntd.0001260

Reader Comments (2)

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Great job for opening big science for looking to resolve big problems in neglected diseases

Posted by Dr_Ambrosio on 17 Nov 2011 at 15:22 GMT

I was really excited on my field after reading this interesting paper. In addition, after knowing that a open forum was open for the interested scientific, I immediately revised the comment on Nature Chemistry. Great job!!! TDR has a page that is indicating that there is a need for applying excelent science to resolve neglected diseases that are affecting a huge numbers of persons and pharmaceutical interests are not sufficient for pushing these kind of efforts. However, these kind of efforts are showing us that there is a good opportunity for share common feelings in order to help to resolve this kind of problems.

I wonder how is the pharmacological action of the enantiomer versus the racemic compound. Other helminths are treated clinically with the same drug. One example are Taenia solium parasites and maybe a good way for evaluating this question is performing in vitro assays in parasite models. Our group is ready for that.

Yours

Dr. Javier Ambrosio
Microbiology and Parasitology Department
School of Medicine
Universidad Nacional Autonoma de Mexico
Mexico city.

No competing interests declared.