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Research Article

Acute Schistosoma mansoni Infection Increases Susceptibility to Systemic SHIV Clade C Infection in Rhesus Macaques after Mucosal Virus Exposure

  • Agnès-Laurence Chenine,

    Affiliations: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Ela Shai-Kobiler,

    Affiliations: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Lisa N. Steele,

    Affiliation: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Helena Ong,

    Affiliation: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Peter Augostini,

    Affiliation: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Ruijiang Song,

    Affiliations: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Sandra J. Lee,

    Affiliation: Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Patrick Autissier,

    Affiliation: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

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  • Ruth M. Ruprecht mail,

    ruth_ruprecht@dfci.harvard.edu (RMR); was4@cdc.gov (WES)

    Affiliations: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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  • W. Evan Secor mail

    ruth_ruprecht@dfci.harvard.edu (RMR); was4@cdc.gov (WES)

    Affiliation: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Published: July 23, 2008
  • DOI: 10.1371/journal.pntd.0000265

Reader Comments (1)

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This could be due to low DHEA.

Posted by jamesmhoward on 23 Jul 2008 at 20:48 GMT

In 1985 I first suggested that low DHEA may result in HIV infection and that loss of DHEA may actually be the cause of AIDS symptoms. The first reports of low DHEA in AIDS appeared in 1989.

It is known that DHEA protects against schistosomiasis (Clin Infect Dis. 2006 Jun 15;42(12):1692-8). I suggest the findings of Chenine, et al., may represent increased susceptibility to the HIV as a result of already low DHEA.