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Research Article

Co-Administration of a Plasmid DNA Encoding IL-15 Improves Long-Term Protection of a Genetic Vaccine against Trypanosoma cruzi

  • Christopher S. Eickhoff equal contributor,

    equal contributor Contributed equally to this work with: Christopher S. Eickhoff, Jose R. Vasconcelos

    Affiliation: Department of Internal Medicine, Saint Louis University, Saint Louis, Missouri, United States of America

    X
  • Jose R. Vasconcelos equal contributor,

    equal contributor Contributed equally to this work with: Christopher S. Eickhoff, Jose R. Vasconcelos

    Affiliations: Department of Internal Medicine, Saint Louis University, Saint Louis, Missouri, United States of America, Centro de Terapia Celular e Molecular, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil

    X
  • Nicole L. Sullivan,

    Affiliation: Department of Molecular Microbiology, Saint Louis University, Saint Louis, Missouri, United States of America

    X
  • Azra Blazevic,

    Affiliation: Department of Internal Medicine, Saint Louis University, Saint Louis, Missouri, United States of America

    X
  • Oscar Bruna-Romero,

    Affiliation: Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil

    X
  • Mauricio M. Rodrigues,

    Affiliation: Centro de Terapia Celular e Molecular, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil

    X
  • Daniel F. Hoft mail

    hoftdf@slu.edu

    Affiliations: Department of Internal Medicine, Saint Louis University, Saint Louis, Missouri, United States of America, Department of Molecular Microbiology, Saint Louis University, Saint Louis, Missouri, United States of America

    X
  • Published: March 08, 2011
  • DOI: 10.1371/journal.pntd.0000983

Reader Comments (1)

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...and over 10,000...

Posted by Polidoro on 27 May 2011 at 16:42 GMT

Over 11 million individuals are infected worldwide with Trypanosoma cruzi, and over 50,000 deaths are attributed to this protozoan parasite annually
http://plosntds.org/article/info:doi/10.1371/journal.pntd.0000983#article1.body1.sec1.p1

Data from WHO says around 11 thousand deaths in 2008 (http://apps.who.int/gb/ebwha/pdf_files/A62/A62_17-en.pdf).

No competing interests declared.