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Research Article

Chemotactic and Inflammatory Responses in the Liver and Brain Are Associated with Pathogenesis of Rift Valley Fever Virus Infection in the Mouse

  • Kimberly K. Gray equal contributor,

    equal contributor Contributed equally to this work with: Kimberly K. Gray, Melissa N. Worthy

    Affiliation: Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Melissa N. Worthy equal contributor,

    equal contributor Contributed equally to this work with: Kimberly K. Gray, Melissa N. Worthy

    Affiliations: Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America, Galveston National Laboratory, The University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Terry L. Juelich,

    Affiliation: Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Stacy L. Agar,

    Affiliation: Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland, United States of America

    X
  • Allison Poussard,

    Affiliations: Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America, Galveston National Laboratory, The University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Dan Ragland,

    Affiliation: Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland, United States of America

    X
  • Alexander N. Freiberg,

    Affiliations: Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America, Galveston National Laboratory, The University of Texas Medical Branch, Galveston, Texas, United States of America, Institute for Human Infections and Immunity, The University of Texas Medical Branch, Galveston, Texas, United States of America, Center for Tropical Diseases, The University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Michael R. Holbrook mail

    Michael.holbrook@nih.gov

    Affiliations: Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas, United States of America, Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America, Galveston National Laboratory, The University of Texas Medical Branch, Galveston, Texas, United States of America, Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland, United States of America, Institute for Human Infections and Immunity, The University of Texas Medical Branch, Galveston, Texas, United States of America, Center for Tropical Diseases, The University of Texas Medical Branch, Galveston, Texas, United States of America

    X
  • Published: February 28, 2012
  • DOI: 10.1371/journal.pntd.0001529

Reader Comments (2)

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ZH501 strain

Posted by deenvet on 01 Mar 2012 at 08:39 GMT

The ZH501 strain of RVFV was isolated during the same 1977 outbreak in Keny
http://plosntds.org/article/info:doi/10.1371/journal.pntd.0001529#article1.body1.sec1.p8

There seems to be a small error here. The RVFV strain known as ZH501 was isolated from a acutely and fatally infected human case at the Zagazig Hospital (ZH) during the 1977 outbreak in Egypt and NOT Kenya.

Niklasson B, Peters CJ, Grandien M, Wood O. Detection of human immunoglobulins
G and M antibodies to Rift Valley fever virus by enzyme-linked immunosorbent
assay. J Clin Microbiol. 1984 Feb;19(2):225-9.

Brown JL, Dominik JW, Morrissey RL. Respiratory infectivity of a recently
isolated Egyptian strain of Rift Valley fever virus. Infect Immun. 1981
Sep;33(3):848-53.
Shamsudeen Fagbo, DVM National Coordinator
Zoonotic Diseases Unit.
General Directorate of Parasitic and Infectious Diseases
Ministry of Health
Riyadh 11176
Email: oloungbo@yahoo.com

No competing interests declared.