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Research Article

Functional and Structural Insights Revealed by Molecular Dynamics Simulations of an Essential RNA Editing Ligase in Trypanosoma brucei

  • Rommie E. Amaro mail,

    ramaro@mccammon.ucsd.edu

    Affiliation: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

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  • Robert V. Swift,

    Affiliation: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America

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  • J. Andrew McCammon

    Affiliations: Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America, NSF Center for Theoretical Biological Physics (CTBP), University of California San Diego, La Jolla, California, United States of America, Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America, Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America

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  • Published: November 14, 2007
  • DOI: 10.1371/journal.pntd.0000068

About the Authors

Rommie E. Amaro, Robert V. Swift, J. Andrew McCammon
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America
J. Andrew McCammon
NSF Center for Theoretical Biological Physics (CTBP), University of California San Diego, La Jolla, California, United States of America
J. Andrew McCammon
Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America
J. Andrew McCammon
Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, United States of America

Corresponding Author

Email: ramaro@mccammon.ucsd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JM RA. Performed the experiments: RA RS. Analyzed the data: RA RS. Contributed reagents/materials/analysis tools: JM RA RS. Wrote the paper: JM RA RS.