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Research Article

Genetic Selection of Low Fertile Onchocerca volvulus by Ivermectin Treatment

  • Catherine Bourguinat,

    Affiliation: Institute of Parasitology, McGill University, Sainte Anne-de-Bellevue, Quebec, Canada

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  • Sébastien D. S. Pion,

    Affiliation: Laboratoire de Neuroparasitologie et Neuroépidémiologie Tropicale, Faculté de Médecine, Limoges Cedex, France

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  • Joseph Kamgno,

    Affiliation: National Onchocerciasis Task Force Cameroon, Yaoundé, Cameroon

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  • Jacques Gardon,

    Affiliation: UR 24 Epidémiologie et Prévention, Institut de Recherche pour le Développement, La Paz, Bolivia

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  • Brian O. L. Duke †,

    † Deceased.

    Affiliation: River Blindness Foundation, Lancaster, United Kingdom

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  • Michel Boussinesq equal contributor,

    equal contributor Contributed equally to this work with: Michel Boussinesq, Roger K. Prichard

    Affiliation: UR 24 Epidémiologie et Prévention, Département Sociétés et Santé, Institut de Recherche pour le Développement, Paris Cedex, France

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  • Roger K. Prichard equal contributor mail

    equal contributor Contributed equally to this work with: Michel Boussinesq, Roger K. Prichard

    roger.prichard@mcgill.ca

    Affiliation: Institute of Parasitology, McGill University, Sainte Anne-de-Bellevue, Quebec, Canada

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  • Published: August 30, 2007
  • DOI: 10.1371/journal.pntd.0000072

About the Authors

Catherine Bourguinat, Roger K. Prichard
Institute of Parasitology, McGill University, Sainte Anne-de-Bellevue, Quebec, Canada
Sébastien D. S. Pion
Laboratoire de Neuroparasitologie et Neuroépidémiologie Tropicale, Faculté de Médecine, Limoges Cedex, France
Joseph Kamgno
National Onchocerciasis Task Force Cameroon, Yaoundé, Cameroon
Jacques Gardon
UR 24 Epidémiologie et Prévention, Institut de Recherche pour le Développement, La Paz, Bolivia
Brian O. L. Duke
River Blindness Foundation, Lancaster, United Kingdom
Michel Boussinesq
UR 24 Epidémiologie et Prévention, Département Sociétés et Santé, Institut de Recherche pour le Développement, Paris Cedex, France

Corresponding Author

Email: roger.prichard@mcgill.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MB RP. Performed the experiments: CB. Analyzed the data: MB RP CB SP. Contributed reagents/materials/analysis tools: MB JK JG BD. Wrote the paper: MB RP CB SP JK. Other: Conducted the field trial and provided the Onchocerca material: JK JG BOLD ML.