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Research Article

Pediatric Measles Vaccine Expressing a Dengue Antigen Induces Durable Serotype-specific Neutralizing Antibodies to Dengue Virus

  • Samantha Brandler,

    Affiliation: Viral Genomics and Vaccination Laboratory, Institut Pasteur, CNRS-URA3015, Paris, France

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  • Marianne Lucas-Hourani,

    Affiliation: Flavivirus-Host Molecular Interactions Unit, Institut Pasteur, Paris, France

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  • Arnaud Moris,

    Affiliation: Virus and Immunity Group, Institut Pasteur, CNRS-URA3015, Paris, France

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  • Marie-Pascale Frenkiel,

    Affiliation: Flavivirus-Host Molecular Interactions Unit, Institut Pasteur, Paris, France

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  • Chantal Combredet,

    Affiliation: Viral Genomics and Vaccination Laboratory, Institut Pasteur, CNRS-URA3015, Paris, France

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  • Michèle Février,

    Affiliation: Viral Genomics and Vaccination Laboratory, Institut Pasteur, CNRS-URA3015, Paris, France

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  • Hugues Bedouelle,

    Affiliation: Molecular Prevention and Therapy of Human Diseases Unit, Institut Pasteur, CNRS-URA3012, Paris, France

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  • Olivier Schwartz,

    Affiliation: Virus and Immunity Group, Institut Pasteur, CNRS-URA3015, Paris, France

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  • Philippe Desprès mail,

    pdespres@pasteur.fr (PD); ftangy@pasteur.fr (FT)

    Affiliation: Flavivirus-Host Molecular Interactions Unit, Institut Pasteur, Paris, France

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  • Frédéric Tangy mail

    pdespres@pasteur.fr (PD); ftangy@pasteur.fr (FT)

    Affiliation: Viral Genomics and Vaccination Laboratory, Institut Pasteur, CNRS-URA3015, Paris, France

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  • Published: December 12, 2007
  • DOI: 10.1371/journal.pntd.0000096

About the Authors

Samantha Brandler, Chantal Combredet, Michèle Février, Frédéric Tangy
Viral Genomics and Vaccination Laboratory, Institut Pasteur, CNRS-URA3015, Paris, France
Marianne Lucas-Hourani, Marie-Pascale Frenkiel, Philippe Desprès
Flavivirus-Host Molecular Interactions Unit, Institut Pasteur, Paris, France
Arnaud Moris, Olivier Schwartz
Virus and Immunity Group, Institut Pasteur, CNRS-URA3015, Paris, France
Hugues Bedouelle
Molecular Prevention and Therapy of Human Diseases Unit, Institut Pasteur, CNRS-URA3012, Paris, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: OS FT PD SB AM. Performed the experiments: MF SB ML AM CC MF. Analyzed the data: FT PD SB. Contributed reagents/materials/analysis tools: PD HB. Wrote the paper: FT SB.