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Research Article

Quantitative High-Throughput Screen Identifies Inhibitors of the Schistosoma mansoni Redox Cascade

  • Anton Simeonov,

    Affiliation: NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Ajit Jadhav,

    Affiliation: NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Ahmed A. Sayed,

    Affiliation: Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America

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  • Yuhong Wang,

    Affiliation: NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Michael E. Nelson,

    Affiliation: NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Craig J. Thomas,

    Affiliation: NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • James Inglese,

    Affiliation: NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • David L. Williams mail,

    dlwilli@ilstu.edu (DLW); austinc@mail.nih.gov (CPA)

    Affiliation: Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America

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  • Christopher P. Austin mail

    dlwilli@ilstu.edu (DLW); austinc@mail.nih.gov (CPA)

    Affiliation: NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Published: January 02, 2008
  • DOI: 10.1371/journal.pntd.0000127
  • Featured in PLOS Collections

About the Authors

Anton Simeonov, Ajit Jadhav, Yuhong Wang, Michael E. Nelson, Craig J. Thomas, James Inglese, Christopher P. Austin
NIH Chemical Genomics Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Ahmed A. Sayed, David L. Williams
Department of Biological Sciences, Illinois State University, Normal, Illinois, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DW AS AAS. Performed the experiments: AS AAS. Analyzed the data: JI CA DW AS AAS AJ MN CT YW. Contributed reagents/materials/analysis tools: AAS AJ MN YW. Wrote the paper: JI CA DW AS AJ CT.