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Research Article

Novel Triazine JPC-2067-B Inhibits Toxoplasma gondii In Vitro and In Vivo

  • Ernest J. Mui,

    Affiliation: Department of Ophthalmology and Visual Science, University of Chicago, Chicago, Illinois, United States of America

    X
  • Guy A. Schiehser,

    Affiliation: Jacobus Pharmaceutical Company, Inc., Princeton, New Jersey, United States of America

    X
  • Wilbur K. Milhous,

    Affiliation: Walter Reed Army Institute for Research, Silver Spring, Maryland, United States of America

    X
  • Honghue Hsu,

    Affiliation: Jacobus Pharmaceutical Company, Inc., Princeton, New Jersey, United States of America

    X
  • Craig W. Roberts,

    Affiliation: Department of Immunology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, Scotland, United Kingdom

    X
  • Michael Kirisits,

    Affiliation: Department of Ophthalmology and Visual Science, University of Chicago, Chicago, Illinois, United States of America

    X
  • Stephen Muench,

    Affiliation: Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, The University of Sheffield, Sheffield, England, United Kingdom

    X
  • David Rice,

    Affiliation: Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, The University of Sheffield, Sheffield, England, United Kingdom

    X
  • J. P. Dubey,

    Affiliation: United States Department of Agriculture, Agricultural Research Services, Animal and Natural Resources Institute, Animal Parasitic Diseases Laboratory, Beltsville, Maryland, United States of America

    X
  • Joseph W. Fowble,

    Affiliation: Department of Chemistry, University of Washington, Seattle, Washington, United States of America

    X
  • Pradipsinh K. Rathod,

    Affiliation: Department of Chemistry, University of Washington, Seattle, Washington, United States of America

    X
  • Sherry F. Queener,

    Affiliation: Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

    X
  • Susan R. Liu,

    Affiliation: Department of Ophthalmology and Visual Science, University of Chicago, Chicago, Illinois, United States of America

    X
  • David P. Jacobus,

    Affiliation: Jacobus Pharmaceutical Company, Inc., Princeton, New Jersey, United States of America

    X
  • Rima McLeod mail

    rmcleod@midway.uchicago.edu

    Affiliations: Department of Ophthalmology and Visual Science, University of Chicago, Chicago, Illinois, United States of America, Department of Pediatrics, Committee on Molecular Medicines, Genetics, and Immunology and The College, University of Chicago, Chicago, Illinois, United States of America

    X
  • Published: March 05, 2008
  • DOI: 10.1371/journal.pntd.0000190

About the Authors

Ernest J. Mui, Michael Kirisits, Susan R. Liu, Rima McLeod
Department of Ophthalmology and Visual Science, University of Chicago, Chicago, Illinois, United States of America
Guy A. Schiehser, Honghue Hsu, David P. Jacobus
Jacobus Pharmaceutical Company, Inc., Princeton, New Jersey, United States of America
Wilbur K. Milhous
Walter Reed Army Institute for Research, Silver Spring, Maryland, United States of America
Craig W. Roberts
Department of Immunology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, Scotland, United Kingdom
Stephen Muench, David Rice
Krebs Institute for Biomolecular Research, Department of Molecular Biology and Biotechnology, The University of Sheffield, Sheffield, England, United Kingdom
J. P. Dubey
United States Department of Agriculture, Agricultural Research Services, Animal and Natural Resources Institute, Animal Parasitic Diseases Laboratory, Beltsville, Maryland, United States of America
Joseph W. Fowble, Pradipsinh K. Rathod
Department of Chemistry, University of Washington, Seattle, Washington, United States of America
Sherry F. Queener
Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
Rima McLeod
Department of Pediatrics, Committee on Molecular Medicines, Genetics, and Immunology and The College, University of Chicago, Chicago, Illinois, United States of America

Corresponding Author

Email: rmcleod@midway.uchicago.edu

Competing Interests

DPJ and Jacobus Pharmaceutical Company are progressing JPC-2056 for the treatment of malaria. The other authors declare that they have no competing financial interests.

Author Contributions

Conceived and designed the experiments: RM PR CR SM GS WM DR JD JF SQ. Performed the experiments: SM EM GS HH MK JD JF SQ SL. Analyzed the data: RM PR CR SM EM GS WM HH DR MK JD JF SQ SL. Contributed reagents/materials/analysis tools: RM PR GS WM JD SQ. Wrote the paper: RM PR CR SM EM GS WM HH DR MK JD JF SQ SL.