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Research Article

Human Leptospirosis Caused by a New, Antigenically Unique Leptospira Associated with a Rattus Species Reservoir in the Peruvian Amazon

  • Michael A. Matthias equal contributor,

    equal contributor Contributed equally to this work with: Michael A. Matthias, Jessica N. Ricaldi

    Affiliation: Division of Infectious Diseases, Department of Medicine, University of California San Diego School of Medicine, La Jolla, California, United States of America

    X
  • Jessica N. Ricaldi equal contributor,

    equal contributor Contributed equally to this work with: Michael A. Matthias, Jessica N. Ricaldi

    Affiliations: Division of Infectious Diseases, Department of Medicine, University of California San Diego School of Medicine, La Jolla, California, United States of America, Alexander von Humboldt Institute of Tropical Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru

    X
  • Manuel Cespedes,

    Affiliation: Leptospirosis Reference Laboratory, National Institute of Health, Lima, Peru

    X
  • M. Monica Diaz,

    Affiliation: CONICET (Consejo de Investigaciones Científicas y Técnicas) and PIDBA (Programa de Investigaciones de Biodiversidad Argentina), Universidad Nacional de Tucumán, Tucumán, Argentina

    X
  • Renee L. Galloway,

    Affiliation: Leptospirosis Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Mayuko Saito,

    Affiliation: Asociacion Benefica PRISMA, Lima, Peru

    X
  • Arnold G. Steigerwalt,

    Affiliation: Leptospirosis Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Kailash P. Patra,

    Affiliation: Division of Infectious Diseases, Department of Medicine, University of California San Diego School of Medicine, La Jolla, California, United States of America

    X
  • Carlos Vidal Ore,

    Affiliation: Directorate of Public Health, Ministry of Health, Loreto Department, Iquitos, Peru

    X
  • Eduardo Gotuzzo,

    Affiliation: Alexander von Humboldt Institute of Tropical Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru

    X
  • Robert H. Gilman,

    Affiliation: Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America

    X
  • Paul N. Levett mail,

    plevett@health.gov.sk.ca (PNL); jvinetz@ucsd.edu (JMV)

    Affiliation: Saskatchewan Disease Control Laboratory, Regina, Saskatchewan, Canada

    X
  • Joseph M. Vinetz mail

    plevett@health.gov.sk.ca (PNL); jvinetz@ucsd.edu (JMV)

    Affiliation: Division of Infectious Diseases, Department of Medicine, University of California San Diego School of Medicine, La Jolla, California, United States of America

    X
  • Published: April 02, 2008
  • DOI: 10.1371/journal.pntd.0000213

About the Authors

Michael A. Matthias, Jessica N. Ricaldi, Kailash P. Patra, Joseph M. Vinetz
Division of Infectious Diseases, Department of Medicine, University of California San Diego School of Medicine, La Jolla, California, United States of America
Jessica N. Ricaldi, Eduardo Gotuzzo
Alexander von Humboldt Institute of Tropical Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru
Manuel Cespedes
Leptospirosis Reference Laboratory, National Institute of Health, Lima, Peru
M. Monica Diaz
CONICET (Consejo de Investigaciones Científicas y Técnicas) and PIDBA (Programa de Investigaciones de Biodiversidad Argentina), Universidad Nacional de Tucumán, Tucumán, Argentina
Renee L. Galloway, Arnold G. Steigerwalt
Leptospirosis Laboratory, Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
Mayuko Saito
Asociacion Benefica PRISMA, Lima, Peru
Carlos Vidal Ore
Directorate of Public Health, Ministry of Health, Loreto Department, Iquitos, Peru
Robert H. Gilman
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
Paul N. Levett
Saskatchewan Disease Control Laboratory, Regina, Saskatchewan, Canada

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MM JR MC MD RLG KP CV EG RHG JV. Performed the experiments: MM JR MC MD RLG AS KP RG. Analyzed the data: MM JR MC MD RLG MS AS KP CV EG RHG PL JV. Contributed reagents/materials/analysis tools: MM JR MC MD RLG AS KP JV. Wrote the paper: MM JR MD RLG MS KP EG RHG PL JV.