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Research Article

Use of Short Tandem Repeat Sequences to Study Mycobacterium leprae in Leprosy Patients in Malawi and India

  • Saroj K. Young,

    Affiliation: Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Jorg M. Ponnighaus,

    Affiliation: Karonga Prevention Study, Chilumba, Karonga District, Malawi

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  • Suman Jain,

    Affiliation: Blue Peter Research Centre, LEPRA Society, Hyderabad, India

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  • Sebastian Lucas,

    Affiliation: Department of Histopathology, Kings College London School of Medicine, St Thomas' Hospital, London, United Kingdom

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  • Sujai Suneetha,

    Affiliation: Blue Peter Research Centre, LEPRA Society, Hyderabad, India

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  • Diana N. J. Lockwood,

    Affiliation: Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Douglas B. Young,

    Affiliation: Centre for Molecular Microbiology and Infection, Division of Investigative Sciences, South Kensington Campus, Imperial College London, London, United Kingdom

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  • Paul E. M. Fine mail

    paul.fine@lshtm.ac.uk

    Affiliation: Infectious Disease Epidemiology Unit, Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Published: April 09, 2008
  • DOI: 10.1371/journal.pntd.0000214

About the Authors

Saroj K. Young, Diana N. J. Lockwood
Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
Jorg M. Ponnighaus
Karonga Prevention Study, Chilumba, Karonga District, Malawi
Suman Jain, Sujai Suneetha
Blue Peter Research Centre, LEPRA Society, Hyderabad, India
Sebastian Lucas
Department of Histopathology, Kings College London School of Medicine, St Thomas' Hospital, London, United Kingdom
Douglas B. Young
Centre for Molecular Microbiology and Infection, Division of Investigative Sciences, South Kensington Campus, Imperial College London, London, United Kingdom
Paul E. M. Fine
Infectious Disease Epidemiology Unit, Department of Epidemiology and Population Sciences, London School of Hygiene and Tropical Medicine, London, United Kingdom

Corresponding Author

Email: paul.fine@lshtm.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SY DL DY PF. Performed the experiments: SY. Analyzed the data: SY PF. Contributed reagents/materials/analysis tools: SY JP SJ SL SS DY. Wrote the paper: SY DY PF. Responsible for the Hyderabad research project: DL. Wrote the first draft of the paper: DY. PI for the Malawi research Programme: PF. Responsible for extracting DNA and genotyping all samples: SY. Did all the clinical, epidemiological, and biopsy work in Malawi: JP. Responsible for the clinical, epidemiological, and biopsy work in India: SJ and SS. Responsible for histopathology (and archiving) of Malawi biopsy material: SL.