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Research Article

Tissue Invasion by Entamoeba histolytica: Evidence of Genetic Selection and/or DNA Reorganization Events in Organ Tropism

  • Ibne Karim M. Ali,

    Affiliations: Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom, Division of Infectious Diseases and International Health, University of Virginia Health System, Charlottesville, Virginia, United States of America

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  • Shahram Solaymani-Mohammadi,

    Affiliations: Division of Infectious Diseases and International Health, University of Virginia Health System, Charlottesville, Virginia, United States of America, Division of Intestinal and Genital Protozoal Diseases, Department of Medical Parasitology and Mycology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran

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  • Jasmine Akhter,

    Affiliation: International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

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  • Shantanu Roy,

    Affiliation: Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

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  • Chiara Gorrini,

    Affiliation: Department of Pathology and Laboratory Medicine, Section of Microbiology, University of Parma, Parma, Italy

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  • Adriana Calderaro,

    Affiliation: Department of Pathology and Laboratory Medicine, Section of Microbiology, University of Parma, Parma, Italy

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  • Sarah K. Parker,

    Affiliation: Department of Pediatrics, Division of Infectious Diseases, University of Colorado Health Sciences Center and The Children's Hospital, Aurora, Colorado, United States of America

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  • Rashidul Haque,

    Affiliation: International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh

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  • William A. Petri Jr. mail,

    wap3g@virginia.edu (WAP); graham.clark@lshtm.ac.uk (CGC)

    Affiliation: Division of Infectious Diseases and International Health, University of Virginia Health System, Charlottesville, Virginia, United States of America

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  • C. Graham Clark mail

    wap3g@virginia.edu (WAP); graham.clark@lshtm.ac.uk (CGC)

    Affiliation: Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom

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  • Published: April 09, 2008
  • DOI: 10.1371/journal.pntd.0000219

About the Authors

Ibne Karim M. Ali, C. Graham Clark
Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, United Kingdom
Ibne Karim M. Ali, Shahram Solaymani-Mohammadi, William A. Petri Jr.
Division of Infectious Diseases and International Health, University of Virginia Health System, Charlottesville, Virginia, United States of America
Shahram Solaymani-Mohammadi
Division of Intestinal and Genital Protozoal Diseases, Department of Medical Parasitology and Mycology, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran
Jasmine Akhter, Rashidul Haque
International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
Shantanu Roy
Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
Chiara Gorrini, Adriana Calderaro
Department of Pathology and Laboratory Medicine, Section of Microbiology, University of Parma, Parma, Italy
Sarah K. Parker
Department of Pediatrics, Division of Infectious Diseases, University of Colorado Health Sciences Center and The Children's Hospital, Aurora, Colorado, United States of America

Corresponding Authors

Competing Interests

W. A. Petri, Jr. received research support from TechLab, Inc. and royalties from a patent license agreement with TechLab for a diagnostic test for amebiasis. These royalties accrue to the American Society of Tropical Medicine and Hygiene without benefit to W. A. Petri, Jr.

Author Contributions

Conceived and designed the experiments: CC. Performed the experiments: IA SS JA CG. Analyzed the data: IA SS CG AC RH WP CC. Contributed reagents/materials/analysis tools: SR AC SP RH. Wrote the paper: IA WP CC. Coordinated collection of Bangladesh samples: RH. Coordinated collection of Italy samples: AC. Coordinated collection of USA samples: SP.