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Research Article

Human TLR1 Deficiency Is Associated with Impaired Mycobacterial Signaling and Protection from Leprosy Reversal Reaction

  • Elizabeth A. Misch,

    Affiliation: University of Washington School of Medicine, Seattle, Washington, United States of America

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  • Murdo Macdonald,

    Affiliation: Mycobacterial Research Laboratory, Anandaban Hospital, Kathmandu, Nepal

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  • Chaman Ranjit,

    Affiliation: Mycobacterial Research Laboratory, Anandaban Hospital, Kathmandu, Nepal

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  • Bishwa R. Sapkota,

    Affiliation: Mycobacterial Research Laboratory, Anandaban Hospital, Kathmandu, Nepal

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  • Richard D. Wells,

    Affiliation: University of Washington School of Medicine, Seattle, Washington, United States of America

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  • M. Ruby Siddiqui,

    Affiliation: Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute at the University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America

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  • Gilla Kaplan,

    Affiliation: Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute at the University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America

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  • Thomas R. Hawn mail

    thawn@u.washington.edu

    Affiliation: University of Washington School of Medicine, Seattle, Washington, United States of America

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  • Published: May 07, 2008
  • DOI: 10.1371/journal.pntd.0000231

About the Authors

Elizabeth A. Misch, Richard D. Wells, Thomas R. Hawn
University of Washington School of Medicine, Seattle, Washington, United States of America
Murdo Macdonald, Chaman Ranjit, Bishwa R. Sapkota
Mycobacterial Research Laboratory, Anandaban Hospital, Kathmandu, Nepal
M. Ruby Siddiqui, Gilla Kaplan
Laboratory of Mycobacterial Immunity and Pathogenesis, Public Health Research Institute at the University of Medicine and Dentistry of New Jersey, Newark, New Jersey, United States of America

Corresponding Author

Email: thawn@u.washington.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EM MM CR BS RW MS GK TH. Performed the experiments: EM CR BS RW MS TH. Analyzed the data: EM MM CR BS RW MS GK TH. Contributed reagents/materials/analysis tools: EM MM MS TH. Wrote the paper: EM MM GK TH.