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Research Article

Age-Related Alteration of Arginase Activity Impacts on Severity of Leishmaniasis

  • Ingrid Müller mail,

    i.muller@imperial.ac.uk (IM); p.kropf@imperial.ac.uk (PK)

    Affiliation: Department of Immunology, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Asrat Hailu,

    Affiliation: Department of Microbiology, Immunology & Parasitology, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia

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  • Beak-San Choi,

    Affiliation: Department of Immunology, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Tamrat Abebe,

    Affiliation: Department of Microbiology, Immunology & Parasitology, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia

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  • Jose M. Fuentes,

    Affiliation: Centro de Investigación Biomédica de Enfermedades Neurodegenerativas (CIBERNED), Departamento de Bioquímica y Biología Molecular, E.U. Enfermería y T.O., Universidad de Extremadura, Cáceres, Spain

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  • Markus Munder,

    Affiliation: Department of Hematology, Oncology, and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany

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  • Manuel Modolell,

    Affiliation: Department of Cellular Immunology, Max-Planck-Institute for Immunobiology, Freiburg, Germany

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  • Pascale Kropf mail

    i.muller@imperial.ac.uk (IM); p.kropf@imperial.ac.uk (PK)

    Affiliation: Department of Immunology, Faculty of Medicine, Imperial College London, London, United Kingdom

    X
  • Published: May 14, 2008
  • DOI: 10.1371/journal.pntd.0000235

About the Authors

Ingrid Müller, Beak-San Choi, Pascale Kropf
Department of Immunology, Faculty of Medicine, Imperial College London, London, United Kingdom
Asrat Hailu, Tamrat Abebe
Department of Microbiology, Immunology & Parasitology, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
Jose M. Fuentes
Centro de Investigación Biomédica de Enfermedades Neurodegenerativas (CIBERNED), Departamento de Bioquímica y Biología Molecular, E.U. Enfermería y T.O., Universidad de Extremadura, Cáceres, Spain
Markus Munder
Department of Hematology, Oncology, and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany
Manuel Modolell
Department of Cellular Immunology, Max-Planck-Institute for Immunobiology, Freiburg, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: I. Müller, P. Kropf. Performed the experiments: I. Müller, A. Hailu, B. Choi, T. Abebe, J. Fuentes, P. Kropf. Analyzed the data: I. Müller, A. Hailu, M. Munder, M. Modolell, P. Kropf. Contributed reagents/materials/analysis tools: I. Müller, P. Kropf. Wrote the paper: I. Müller, P. Kropf.