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Research Article

Differentiation and Gene Flow among European Populations of Leishmania infantum MON-1

  • Katrin Kuhls mail,

    Katrin.Kuhls@charite.de

    Affiliation: Institut für Mikrobiologie und Hygiene, Charité Universitätsmedizin Berlin, Berlin, Germany

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  • Carmen Chicharro,

    Affiliation: WHO Collaborating Centre for Leishmaniasis, Servicio de Parasitología, Instituto de Salud Carlos III, Mahadahonda (Madrid), Spain

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  • Carmen Cañavate,

    Affiliation: WHO Collaborating Centre for Leishmaniasis, Servicio de Parasitología, Instituto de Salud Carlos III, Mahadahonda (Madrid), Spain

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  • Sofia Cortes,

    Affiliation: Unidade de Leishmanioses, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal

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  • Lenea Campino,

    Affiliation: Unidade de Leishmanioses, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal

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  • Christos Haralambous,

    Affiliation: Laboratory of Molecular Parasitology, Hellenic Pasteur Institute, Athens, Greece

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  • Ketty Soteriadou,

    Affiliation: Laboratory of Molecular Parasitology, Hellenic Pasteur Institute, Athens, Greece

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  • Francine Pratlong,

    Affiliation: Laboratoire de Parasitologie and Centre National de Référence des Leishmania, Université Montpellier 1 and CHU Montpellier, Montpellier, France

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  • Jean-Pierre Dedet,

    Affiliation: Laboratoire de Parasitologie and Centre National de Référence des Leishmania, Université Montpellier 1 and CHU Montpellier, Montpellier, France

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  • Isabel Mauricio,

    Affiliation: Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Michael Miles,

    Affiliation: Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

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  • Matthias Schaar,

    Affiliation: Institut für Mikrobiologie und Hygiene, Charité Universitätsmedizin Berlin, Berlin, Germany

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  • Sebastian Ochsenreither,

    Affiliation: Institut für Mikrobiologie und Hygiene, Charité Universitätsmedizin Berlin, Berlin, Germany

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  • Oliver A. Radtke,

    Affiliation: Institut für Mikrobiologie und Hygiene, Charité Universitätsmedizin Berlin, Berlin, Germany

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  • Gabriele Schönian

    Affiliation: Institut für Mikrobiologie und Hygiene, Charité Universitätsmedizin Berlin, Berlin, Germany

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  • Published: July 09, 2008
  • DOI: 10.1371/journal.pntd.0000261

About the Authors

Katrin Kuhls, Matthias Schaar, Sebastian Ochsenreither, Oliver A. Radtke, Gabriele Schönian
Institut für Mikrobiologie und Hygiene, Charité Universitätsmedizin Berlin, Berlin, Germany
Carmen Chicharro, Carmen Cañavate
WHO Collaborating Centre for Leishmaniasis, Servicio de Parasitología, Instituto de Salud Carlos III, Mahadahonda (Madrid), Spain
Sofia Cortes, Lenea Campino
Unidade de Leishmanioses, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal
Christos Haralambous, Ketty Soteriadou
Laboratory of Molecular Parasitology, Hellenic Pasteur Institute, Athens, Greece
Francine Pratlong, Jean-Pierre Dedet
Laboratoire de Parasitologie and Centre National de Référence des Leishmania, Université Montpellier 1 and CHU Montpellier, Montpellier, France
Isabel Mauricio, Michael Miles
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom

Corresponding Author

Email: Katrin.Kuhls@charite.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

C. Cañavate, L. Campino, K. Soteriadou, J. Dedet, I. Mauricio, M. Miles, G. Schönian conceived the project of typing of European L. infantum. K. Kuhls and G. Schönian designed the experiments and analyzed the data. K. Kuhls, C. Chicharro, S. Cortes, C. Haralambous, M. Schaar, S. Ochsenreither, O. Radtke performed the experiments. K. Kuhls, I. Mauricio, G. Schönian wrote the paper. C. Chicharro, C. Cañavate, S. Cortes, L. Campino, C. Haralambous, K. Soteriadou, F. Pratlong, J. Dedet, I. Mauricio, M. Miles collected strains and/or provided the DNA. F. Pratlong and J. Dedet performed MLEE typing.