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Research Article

Acute Schistosoma mansoni Infection Increases Susceptibility to Systemic SHIV Clade C Infection in Rhesus Macaques after Mucosal Virus Exposure

  • Agnès-Laurence Chenine,

    Affiliations: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Ela Shai-Kobiler,

    Affiliations: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Lisa N. Steele,

    Affiliation: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Helena Ong,

    Affiliation: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Peter Augostini,

    Affiliation: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Ruijiang Song,

    Affiliations: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Sandra J. Lee,

    Affiliation: Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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  • Patrick Autissier,

    Affiliation: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

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  • Ruth M. Ruprecht mail,

    ruth_ruprecht@dfci.harvard.edu (RMR); was4@cdc.gov (WES)

    Affiliations: Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • W. Evan Secor mail

    ruth_ruprecht@dfci.harvard.edu (RMR); was4@cdc.gov (WES)

    Affiliation: Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

    X
  • Published: July 23, 2008
  • DOI: 10.1371/journal.pntd.0000265

About the Authors

Agnès-Laurence Chenine, Ela Shai-Kobiler, Helena Ong, Ruijiang Song, Ruth M. Ruprecht
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
Agnès-Laurence Chenine, Ela Shai-Kobiler, Ruijiang Song, Ruth M. Ruprecht
Harvard Medical School, Boston, Massachusetts, United States of America
Lisa N. Steele, Peter Augostini, W. Evan Secor
Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
Sandra J. Lee
Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
Patrick Autissier
Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: A. Chenine, R. Ruprecht, W. Secor. Performed the experiments: A. Chenine, E. Shai-Kobiler, L. Steele, H. Ong, P. Augostini, P. Autissier, W. Secor. Analyzed the data: A. Chenine, S. Lee, P. Autissier, R. Ruprecht, W. Secor. Contributed reagents/materials/analysis tools: A. Chenine, P. Augostini, R. Song, S. Lee, P. Autissier, W. Secor. Wrote the paper: A. Chenine, R. Ruprecht, W. Secor.