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Research Article

HLA Class I-T Cell Epitopes from trans-Sialidase Proteins Reveal Functionally Distinct Subsets of CD8+ T Cells in Chronic Chagas Disease

  • María G. Alvarez,

    Affiliation: Hospital Interzonal General de Agudos “Eva Perón”, San Martín, Provincia de Buenos Aires, Argentina

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  • Miriam Postan,

    Affiliation: Instituto Nacional de Parasitología “Dr. Mario Fatala Chabén”, Buenos Aires, Argentina

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  • D. Brent Weatherly,

    Affiliation: Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

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  • María C. Albareda,

    Affiliation: Instituto Nacional de Parasitología “Dr. Mario Fatala Chabén”, Buenos Aires, Argentina

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  • John Sidney,

    Affiliation: La Jolla Institute of Allergy and Immunology, La Jolla, California, United States of America

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  • Alessandro Sette,

    Affiliation: La Jolla Institute of Allergy and Immunology, La Jolla, California, United States of America

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  • Carina Olivera,

    Affiliation: Instituto Nacional de Parasitología “Dr. Mario Fatala Chabén”, Buenos Aires, Argentina

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  • Alejandro H. Armenti,

    Affiliation: Hospital Interzonal General de Agudos “Eva Perón”, San Martín, Provincia de Buenos Aires, Argentina

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  • Rick L. Tarleton equal contributor,

    equal contributor Contributed equally to this work with: Rick L. Tarleton, Susana A. Laucella

    Affiliation: Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America

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  • Susana A. Laucella equal contributor mail

    equal contributor Contributed equally to this work with: Rick L. Tarleton, Susana A. Laucella

    slaucella@yahoo.com

    Affiliation: Instituto Nacional de Parasitología “Dr. Mario Fatala Chabén”, Buenos Aires, Argentina

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  • Published: September 03, 2008
  • DOI: 10.1371/journal.pntd.0000288

About the Authors

María G. Alvarez, Alejandro H. Armenti
Hospital Interzonal General de Agudos “Eva Perón”, San Martín, Provincia de Buenos Aires, Argentina
Miriam Postan, María C. Albareda, Carina Olivera, Susana A. Laucella
Instituto Nacional de Parasitología “Dr. Mario Fatala Chabén”, Buenos Aires, Argentina
D. Brent Weatherly, Rick L. Tarleton
Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America
John Sidney, Alessandro Sette
La Jolla Institute of Allergy and Immunology, La Jolla, California, United States of America

Corresponding Author

Email: slaucella@yahoo.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RLT SAL. Performed the experiments: MGA MCA CO. Analyzed the data: MGA MP DBW JS AS SAL. Contributed reagents/materials/analysis tools: DBW MCA JS AS AHA RLT. Wrote the paper: MP RLT SAL.