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Research Article

Protective and Enhancing HLA Alleles, HLA-DRB1*0901 and HLA-A*24, for Severe Forms of Dengue Virus Infection, Dengue Hemorrhagic Fever and Dengue Shock Syndrome

  • Nguyen Thi Phuong Lan,

    Affiliation: Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan

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  • Mihoko Kikuchi,

    Affiliations: Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan, Center of International Collaborative Research, Nagasaki University, Japan

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  • Vu Thi Que Huong,

    Affiliations: Laboratory of Arbovirus, Pasteur Institute in Ho Chi Minh City, Vietnam, Laboratory of Arbovirus, Pasteur Institute in Ho Chi Minh City, Vietnam

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  • Do Quang Ha,

    Affiliation: Laboratory of Arbovirus, Pasteur Institute in Ho Chi Minh City, Vietnam

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  • Tran Thi Thuy,

    Affiliation: Children's Hospital No.2, Ho Chi Minh City, Vietnam

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  • Vo Dinh Tham,

    Affiliation: Children's Hospital No.2, Ho Chi Minh City, Vietnam

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  • Ha Manh Tuan,

    Affiliation: Children's Hospital No.2, Ho Chi Minh City, Vietnam

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  • Vo Van Tuong,

    Affiliation: Center for Preventive Medicine, Vinh Long Province, Vietnam

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  • Cao Thi Phi Nga,

    Affiliation: Center for Preventive Medicine, Vinh Long Province, Vietnam

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  • Tran Van Dat,

    Affiliation: Center for Preventive Medicine, Vinh Long Province, Vietnam

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  • Toshifumi Oyama,

    Affiliation: Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan

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  • Kouichi Morita,

    Affiliations: Global COE program, Nagasaki University, Japan, Department of Virology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan

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  • Michio Yasunami,

    Affiliation: Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan

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  • Kenji Hirayama mail

    hiraken@nagasaki-u.ac.jp

    Affiliations: Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan, Center of International Collaborative Research, Nagasaki University, Japan, Global COE program, Nagasaki University, Japan

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  • Published: October 01, 2008
  • DOI: 10.1371/journal.pntd.0000304

About the Authors

Nguyen Thi Phuong Lan, Mihoko Kikuchi, Toshifumi Oyama, Michio Yasunami, Kenji Hirayama
Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan
Mihoko Kikuchi, Kenji Hirayama
Center of International Collaborative Research, Nagasaki University, Japan
Vu Thi Que Huong, Vu Thi Que Huong, Do Quang Ha
Laboratory of Arbovirus, Pasteur Institute in Ho Chi Minh City, Vietnam
Tran Thi Thuy, Vo Dinh Tham, Ha Manh Tuan
Children's Hospital No.2, Ho Chi Minh City, Vietnam
Vo Van Tuong, Cao Thi Phi Nga, Tran Van Dat
Center for Preventive Medicine, Vinh Long Province, Vietnam
Kouichi Morita, Kenji Hirayama
Global COE program, Nagasaki University, Japan
Kouichi Morita
Department of Virology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan

Corresponding Author

Email: hiraken@nagasaki-u.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NTPL MK VTQH DQH TTT VDT HMT TVD KM MY KH. Performed the experiments: NTPL MK VTQH MY KH. Analyzed the data: NTPL MK VTQH MY KH. Contributed reagents/materials/analysis tools: NTPL MK VTQH DQH TTT VDT HMT VVT CTPN TVD TO KM MY KH. Wrote the paper: NTPL MK VTQH KM MY KH.