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Research Article

Dermal-Type Macrophages Expressing CD209/DC-SIGN Show Inherent Resistance to Dengue Virus Growth

  • Wing-Hong Kwan equal contributor,

    equal contributor Contributed equally to this work with: Wing-Hong Kwan, Erika Navarro-Sanchez

    Affiliations: CNRS, Laboratory of Therapeutic Immunology and Chemistry, IBMC, Université Louis Pasteur, Strasbourg, France, INSERM U872, Centre de Recherches Biomédicales des Cordeliers, Paris V UMRS 872, France, INSERM U872, Centre de Recherches Biomédicales des Cordeliers, Paris VI UMRS 872, France

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  • Erika Navarro-Sanchez equal contributor,

    equal contributor Contributed equally to this work with: Wing-Hong Kwan, Erika Navarro-Sanchez

    Affiliations: Unité Interactions Moléculaires Flavivirus-Hôtes, Institut Pasteur, Paris, France, Unité de Recherche de Virologie Structurale, CNRS URA 3015, Institut Pasteur, Paris, France

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  • Hélène Dumortier,

    Affiliation: CNRS, Laboratory of Therapeutic Immunology and Chemistry, IBMC, Université Louis Pasteur, Strasbourg, France

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  • Marion Decossas,

    Affiliation: CNRS, Laboratory of Therapeutic Immunology and Chemistry, IBMC, Université Louis Pasteur, Strasbourg, France

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  • Hortense Vachon,

    Affiliation: CNRS, Laboratory of Therapeutic Immunology and Chemistry, IBMC, Université Louis Pasteur, Strasbourg, France

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  • Flavia Barreto dos Santos,

    Affiliation: Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California, United States of America

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  • Hervé W. Fridman,

    Affiliations: INSERM U872, Centre de Recherches Biomédicales des Cordeliers, Paris V UMRS 872, France, INSERM U872, Centre de Recherches Biomédicales des Cordeliers, Paris VI UMRS 872, France

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  • Félix A. Rey,

    Affiliation: Unité de Recherche de Virologie Structurale, CNRS URA 3015, Institut Pasteur, Paris, France

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  • Eva Harris,

    Affiliation: Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California, United States of America

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  • Philippe Despres mail,

    pdespres@pasteur.fr (PD); c.mueller@ibmc.u-strasbg.fr (CGM)

    Affiliation: Unité Interactions Moléculaires Flavivirus-Hôtes, Institut Pasteur, Paris, France

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  • Christopher G. Mueller mail

    pdespres@pasteur.fr (PD); c.mueller@ibmc.u-strasbg.fr (CGM)

    Affiliation: CNRS, Laboratory of Therapeutic Immunology and Chemistry, IBMC, Université Louis Pasteur, Strasbourg, France

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  • Published: October 01, 2008
  • DOI: 10.1371/journal.pntd.0000311

About the Authors

Wing-Hong Kwan, Hélène Dumortier, Marion Decossas, Hortense Vachon, Christopher G. Mueller
CNRS, Laboratory of Therapeutic Immunology and Chemistry, IBMC, Université Louis Pasteur, Strasbourg, France
Wing-Hong Kwan, Hervé W. Fridman
INSERM U872, Centre de Recherches Biomédicales des Cordeliers, Paris V UMRS 872, France
Wing-Hong Kwan, Hervé W. Fridman
INSERM U872, Centre de Recherches Biomédicales des Cordeliers, Paris VI UMRS 872, France
Erika Navarro-Sanchez, Philippe Despres
Unité Interactions Moléculaires Flavivirus-Hôtes, Institut Pasteur, Paris, France
Erika Navarro-Sanchez, Félix A. Rey
Unité de Recherche de Virologie Structurale, CNRS URA 3015, Institut Pasteur, Paris, France
Flavia Barreto dos Santos, Eva Harris
Division of Infectious Diseases, School of Public Health, University of California, Berkeley, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WHK ENS HD MD EH PD CGM. Performed the experiments: WHK ENS HD MD HV FBdS CGM. Analyzed the data: WHK ENS HD MD HV FBdS EH PD CGM. Contributed reagents/materials/analysis tools: WHK ENS HD HV FBdS HWF FAR EH PD CGM. Wrote the paper: PD CGM.