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Research Article

Mycolactone Diffuses from Mycobacterium ulcerans–Infected Tissues and Targets Mononuclear Cells in Peripheral Blood and Lymphoid Organs

  • Hui Hong,

    Affiliation: University of Cambridge, Department of Biochemistry, Cambridge, United Kingdom

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  • Emmanuelle Coutanceau,

    Affiliation: Institut Pasteur, UP Pathogénomique Mycobactérienne Intégrée, Paris, France

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  • Marion Leclerc,

    Affiliation: Institut Pasteur, UP Pathogénomique Mycobactérienne Intégrée, Paris, France

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  • Laxmee Caleechurn,

    Affiliation: Institut Pasteur, UP Pathogénomique Mycobactérienne Intégrée, Paris, France

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  • Peter F. Leadlay,

    Affiliation: University of Cambridge, Department of Biochemistry, Cambridge, United Kingdom

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  • Caroline Demangel mail

    demangel@pasteur.fr

    Affiliation: Institut Pasteur, UP Pathogénomique Mycobactérienne Intégrée, Paris, France

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  • Published: October 22, 2008
  • DOI: 10.1371/journal.pntd.0000325

About the Authors

Hui Hong, Peter F. Leadlay
University of Cambridge, Department of Biochemistry, Cambridge, United Kingdom
Emmanuelle Coutanceau, Marion Leclerc, Laxmee Caleechurn, Caroline Demangel
Institut Pasteur, UP Pathogénomique Mycobactérienne Intégrée, Paris, France

Corresponding Author

Email: demangel@pasteur.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EC PFL CD. Performed the experiments: HH EC ML LC CD. Analyzed the data: HH ML LC CD. Wrote the paper: CD.