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Research Article

Immunogenicity of Fractional Doses of Tetravalent A/C/Y/W135 Meningococcal Polysaccharide Vaccine: Results from a Randomized Non-Inferiority Controlled Trial in Uganda

  • Philippe J. Guerin mail,

    philippe.guerin@epicentre.msf.org

    Affiliations: Epicentre, Paris, France, Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway, Centre for Prevention of Global Infections, University of Oslo, Oslo, Norway

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  • Lisbeth M. Næss,

    Affiliations: Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway, Centre for Prevention of Global Infections, University of Oslo, Oslo, Norway

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  • Carole Fogg,

    Affiliation: Epicentre, Paris, France

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  • Einar Rosenqvist,

    Affiliations: Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway, Centre for Prevention of Global Infections, University of Oslo, Oslo, Norway

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  • Loretxu Pinoges,

    Affiliation: Epicentre, Paris, France

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  • Francis Bajunirwe,

    Affiliations: Epicentre, Paris, France, Mbarara University of Science and Technology, Mbarara, Uganda

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  • Carolyn Nabasumba,

    Affiliation: Epicentre, Paris, France

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  • Ray Borrow,

    Affiliation: Health Protection Agency, Manchester, United Kingdom

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  • Leif O. Frøholm,

    Affiliation: Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway

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  • Salah Ghabri,

    Affiliation: Epicentre, Paris, France

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  • Vincent Batwala,

    Affiliations: Epicentre, Paris, France, Mbarara University of Science and Technology, Mbarara, Uganda

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  • Rogers Twesigye,

    Affiliation: Epicentre, Paris, France

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  • Ingeborg S. Aaberge,

    Affiliations: Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway, Centre for Prevention of Global Infections, University of Oslo, Oslo, Norway

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  • John-Arne Røttingen,

    Affiliations: Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway, Centre for Prevention of Global Infections, University of Oslo, Oslo, Norway, Norwegian Knowledge Centre for the Health Services, Oslo, Norway

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  • Patrice Piola,

    Affiliation: Epicentre, Paris, France

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  • Dominique A. Caugant

    Affiliations: Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway, Centre for Prevention of Global Infections, University of Oslo, Oslo, Norway, Department of Oral Biology, University of Oslo, Oslo, Norway

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  • Published: December 02, 2008
  • DOI: 10.1371/journal.pntd.0000342

About the Authors

Philippe J. Guerin, Carole Fogg, Loretxu Pinoges, Francis Bajunirwe, Carolyn Nabasumba, Salah Ghabri, Vincent Batwala, Rogers Twesigye, Patrice Piola
Epicentre, Paris, France
Philippe J. Guerin, Lisbeth M. Næss, Einar Rosenqvist, Leif O. Frøholm, Ingeborg S. Aaberge, John-Arne Røttingen, Dominique A. Caugant
Division of Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway
Philippe J. Guerin, Lisbeth M. Næss, Einar Rosenqvist, Ingeborg S. Aaberge, John-Arne Røttingen, Dominique A. Caugant
Centre for Prevention of Global Infections, University of Oslo, Oslo, Norway
Francis Bajunirwe, Vincent Batwala
Mbarara University of Science and Technology, Mbarara, Uganda
Ray Borrow
Health Protection Agency, Manchester, United Kingdom
John-Arne Røttingen
Norwegian Knowledge Centre for the Health Services, Oslo, Norway
Dominique A. Caugant
Department of Oral Biology, University of Oslo, Oslo, Norway

Corresponding Author

Email: philippe.guerin@epicentre.msf.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PJG LMN ER LOF ISA JAR DAC. Performed the experiments: LMN CF FB CN RB VB RT PP DAC. Analyzed the data: PJG LMN LP SG PP. Contributed reagents/materials/analysis tools: PJG LMN ER LP RB SG PP DAC. Wrote the paper: PJG LMN CF ER FB CN LOF ISA JAR PP DAC.