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Research Article

The Importance of pH in Regulating the Function of the Fasciola hepatica Cathepsin L1 Cysteine Protease

  • Jonathan Lowther,

    Affiliation: Institute for the Biotechnology of Infectious Diseases (IBID), University of Technology Sydney (UTS), Ultimo, Sydney, New South Wales, Australia

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  • Mark W. Robinson,

    Affiliation: Institute for the Biotechnology of Infectious Diseases (IBID), University of Technology Sydney (UTS), Ultimo, Sydney, New South Wales, Australia

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  • Sheila M. Donnelly,

    Affiliation: Institute for the Biotechnology of Infectious Diseases (IBID), University of Technology Sydney (UTS), Ultimo, Sydney, New South Wales, Australia

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  • Weibo Xu,

    Affiliation: Institute for the Biotechnology of Infectious Diseases (IBID), University of Technology Sydney (UTS), Ultimo, Sydney, New South Wales, Australia

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  • Colin M. Stack,

    Affiliation: Institute for the Biotechnology of Infectious Diseases (IBID), University of Technology Sydney (UTS), Ultimo, Sydney, New South Wales, Australia

    Current address: Department of Medical Microbiology, University of Western Sydney (UWS), Narellan Road, Campbelltown, New South Wales, Australia

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  • Jacqueline M. Matthews,

    Affiliation: School of Molecular and Microbial Biosciences, University of Sydney, New South Wales, Australia

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  • John P. Dalton mail

    john.dalton@uts.edu.au

    Affiliation: Institute for the Biotechnology of Infectious Diseases (IBID), University of Technology Sydney (UTS), Ultimo, Sydney, New South Wales, Australia

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  • Published: January 27, 2009
  • DOI: 10.1371/journal.pntd.0000369

About the Authors

Jonathan Lowther, Mark W. Robinson, Sheila M. Donnelly, Weibo Xu, Colin M. Stack, John P. Dalton
Institute for the Biotechnology of Infectious Diseases (IBID), University of Technology Sydney (UTS), Ultimo, Sydney, New South Wales, Australia
Jacqueline M. Matthews
School of Molecular and Microbial Biosciences, University of Sydney, New South Wales, Australia

Corresponding Author

Email: john.dalton@uts.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JL JMM JPD. Performed the experiments: JL MWR WX CMS. Analyzed the data: JL MWR JMM. Contributed reagents/materials/analysis tools: SMD CMS JMM. Wrote the paper: JL MWR SMD JPD.