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Research Article

Trypanosoma cruzi CYP51 Inhibitor Derived from a Mycobacterium tuberculosis Screen Hit

  • Chiung-Kuang Chen,

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

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  • Patricia S. Doyle,

    Affiliation: Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, California, United States of America

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  • Liudmila V. Yermalitskaya,

    Affiliation: Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Zachary B. Mackey,

    Affiliation: Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, California, United States of America

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  • Kenny K. H. Ang,

    Affiliation: Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, California, United States of America

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  • James H. McKerrow,

    Affiliation: Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, California, United States of America

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  • Larissa M. Podust mail

    larissa.podust@ucsf.edu

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

    X
  • Published: February 03, 2009
  • DOI: 10.1371/journal.pntd.0000372

About the Authors

Chiung-Kuang Chen, Larissa M. Podust
Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America
Patricia S. Doyle, Zachary B. Mackey, Kenny K. H. Ang, James H. McKerrow
Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, California, United States of America
Liudmila V. Yermalitskaya
Department of Pharmacology, Vanderbilt University, Nashville, Tennessee, United States of America

Corresponding Author

Email: larissa.podust@ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PSD JHM LMP. Performed the experiments: CKC PSD LVY ZBM KKHA LMP. Analyzed the data: PSD ZBM LMP. Contributed reagents/materials/analysis tools: PSD JHM LMP. Wrote the paper: LMP.