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Research Article

Cardiac Alterations in Human African Trypanosomiasis (T.b. gambiense) with Respect to the Disease Stage and Antiparasitic Treatment

  • Johannes A. Blum mail,

    johannes.blum@unibas.ch

    Affiliation: Swiss Tropical Institute, Basel, Switzerland

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  • Caecilia Schmid,

    Affiliation: Swiss Tropical Institute, Basel, Switzerland

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  • Christian Burri,

    Affiliation: Swiss Tropical Institute, Basel, Switzerland

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  • Christoph Hatz,

    Affiliation: Swiss Tropical Institute, Basel, Switzerland

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  • Carol Olson,

    Affiliation: Immtech Pharmaceuticals Inc., Vernon Hills, Illinois, United States of America

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  • Blaise Fungula,

    Affiliation: Hôpital Evangélique de Vanga, Vanga, Democratic Republic of Congo

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  • Leon Kazumba,

    Affiliation: Centre Neuro Psycho Pathologique, Kinshasa, Democratic Republic of Congo

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  • Patrick Mangoni,

    Affiliation: Hôpital Evangélique de Vanga, Vanga, Democratic Republic of Congo

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  • Florent Mbo,

    Affiliation: Hôpital General de Reference Bandundu, Bandundu, Democratic Republic of Congo

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  • Kambau Deo,

    Affiliation: Hôpital Evangélique de Kikongo, Kikongo, Democratic Republic of Congo

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  • Alain Mpanya,

    Affiliation: CDTC Maluku, Maluku, Democratic Republic of Congo

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  • Amadeo Dala,

    Affiliation: Instituto de Combate e de Controlo das Tripanossomíases, Luanda, Angola

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  • Jose R. Franco,

    Affiliation: Malteser International, Malteser Hospital, Yei, Southern Sudan

    Current address: Control of Neglected Tropical Diseases, Innovative and Intensified Disease Management, World Health Organization, Geneva, Switzerland

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  • Gabriele Pohlig,

    Affiliation: Swiss Tropical Institute, Basel, Switzerland

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  • Michael J. Zellweger

    Affiliation: Cardiology Department, University Hospital, Basel, Switzerland

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  • Published: February 17, 2009
  • DOI: 10.1371/journal.pntd.0000383

About the Authors

Johannes A. Blum, Caecilia Schmid, Christian Burri, Christoph Hatz, Gabriele Pohlig
Swiss Tropical Institute, Basel, Switzerland
Carol Olson
Immtech Pharmaceuticals Inc., Vernon Hills, Illinois, United States of America
Blaise Fungula, Patrick Mangoni
Hôpital Evangélique de Vanga, Vanga, Democratic Republic of Congo
Leon Kazumba
Centre Neuro Psycho Pathologique, Kinshasa, Democratic Republic of Congo
Florent Mbo
Hôpital General de Reference Bandundu, Bandundu, Democratic Republic of Congo
Kambau Deo
Hôpital Evangélique de Kikongo, Kikongo, Democratic Republic of Congo
Alain Mpanya
CDTC Maluku, Maluku, Democratic Republic of Congo
Amadeo Dala
Instituto de Combate e de Controlo das Tripanossomíases, Luanda, Angola
Jose R. Franco
Malteser International, Malteser Hospital, Yei, Southern Sudan
Michael J. Zellweger
Cardiology Department, University Hospital, Basel, Switzerland

Corresponding Author

Email: johannes.blum@unibas.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JAB CB CH CO GP MJZ. Performed the experiments: JAB BF LK PM FM DK AM AD JRF GP. Analyzed the data: JAB CS CB CO MJZ. Wrote the paper: JAB CB CH MJZ. Critically reviewed the paper: CH CO. Patient recruitment and examinations: BF LK PM FM DK AM AD JRF.