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Research Article

Inhibition of Lassa Virus Glycoprotein Cleavage and Multicycle Replication by Site 1 Protease-Adapted α1-Antitrypsin Variants

  • Anna Maisa,

    Affiliation: Institut für Virologie, Philipps-Universität Marburg, Marburg, Germany

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  • Ute Ströher,

    Affiliations: Molecular Virology & Antiviral Approaches Unit, Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada, Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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  • Hans-Dieter Klenk,

    Affiliation: Institut für Virologie, Philipps-Universität Marburg, Marburg, Germany

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  • Wolfgang Garten mail,

    garten@mailer.uni-marburg.de

    Affiliation: Institut für Virologie, Philipps-Universität Marburg, Marburg, Germany

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  • Thomas Strecker

    Affiliation: Institut für Virologie, Philipps-Universität Marburg, Marburg, Germany

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  • Published: June 02, 2009
  • DOI: 10.1371/journal.pntd.0000446

About the Authors

Anna Maisa, Hans-Dieter Klenk, Wolfgang Garten, Thomas Strecker
Institut für Virologie, Philipps-Universität Marburg, Marburg, Germany
Ute Ströher
Molecular Virology & Antiviral Approaches Unit, Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
Ute Ströher
Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

Corresponding Author

Email: garten@mailer.uni-marburg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WG TS. Performed the experiments: AM TS. Analyzed the data: AM WG TS. Contributed reagents/materials/analysis tools: US. Wrote the paper: AM HDK WG TS.