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Research Article

T. cruzi OligoC-TesT: A Simplified and Standardized Polymerase Chain Reaction Format for Diagnosis of Chagas Disease

  • Stijn Deborggraeve mail,

    sdeborggraeve@itg.be

    Affiliations: Department of Parasitology, Institute of Tropical Medicine Antwerp, Antwerp, Belgium, Laboratory of Medicinal Chemistry, Rega Institute for Medicinal Research, Katholieke Universiteit Leuven, Leuven, Belgium

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  • Ximena Coronado,

    Affiliation: Program of Molecular and Cellular Biology, Faculty of Medicine, University of Chile, Santiago, Chile

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  • Aldo Solari,

    Affiliation: Program of Molecular and Cellular Biology, Faculty of Medicine, University of Chile, Santiago, Chile

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  • Ines Zulantay,

    Affiliation: Program of Molecular and Cellular Biology, Faculty of Medicine, University of Chile, Santiago, Chile

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  • Werner Apt,

    Affiliation: Program of Molecular and Cellular Biology, Faculty of Medicine, University of Chile, Santiago, Chile

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  • Pascal Mertens,

    Affiliation: Coris BioConcept, Gembloux, Belgium

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  • Thierry Laurent,

    Affiliation: Coris BioConcept, Gembloux, Belgium

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  • Thierry Leclipteux,

    Affiliation: Coris BioConcept, Gembloux, Belgium

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  • Tim Stessens,

    Affiliation: Department of Parasitology, Institute of Tropical Medicine Antwerp, Antwerp, Belgium

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  • Jean-Claude Dujardin,

    Affiliation: Department of Parasitology, Institute of Tropical Medicine Antwerp, Antwerp, Belgium

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  • Piet Herdewijn,

    Affiliation: Laboratory of Medicinal Chemistry, Rega Institute for Medicinal Research, Katholieke Universiteit Leuven, Leuven, Belgium

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  • Philippe Büscher

    Affiliation: Department of Parasitology, Institute of Tropical Medicine Antwerp, Antwerp, Belgium

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  • Published: June 02, 2009
  • DOI: 10.1371/journal.pntd.0000450

About the Authors

Stijn Deborggraeve, Tim Stessens, Jean-Claude Dujardin, Philippe Büscher
Department of Parasitology, Institute of Tropical Medicine Antwerp, Antwerp, Belgium
Stijn Deborggraeve, Piet Herdewijn
Laboratory of Medicinal Chemistry, Rega Institute for Medicinal Research, Katholieke Universiteit Leuven, Leuven, Belgium
Ximena Coronado, Aldo Solari, Ines Zulantay, Werner Apt
Program of Molecular and Cellular Biology, Faculty of Medicine, University of Chile, Santiago, Chile
Pascal Mertens, Thierry Laurent, Thierry Leclipteux
Coris BioConcept, Gembloux, Belgium

Corresponding Author

Email: sdeborggraeve@itg.be

Competing Interests

P. Mertens, T. Laurent, and T. Leclipteux are employees of Coris BioConcept, a company involved in the development and provisioning of the OligoC-TesT. All other authors report no potential conflicts.

Author Contributions

Conceived and designed the experiments: S. Deborggraeve, A. Solari, J. Dujardin, P. Herdewijn, P. Büscher. Performed the experiments: S. Deborggraeve, X. Coronado, P. Mertens, T. Laurent, T. Stessens. Analyzed the data: S. Deborggraeve, A. Solari. Contributed reagents/materials/analysis tools: S. Deborggraeve, P. Mertens, T. Laurent, T. Leclipteux. Wrote the paper: S. Deborggraeve. Substantial revision of the manuscript: X. Coronado, A. Solari, I. Zulantay, W. Apt, P. Mertens, T. Laurent, T. Leclipteux, T. Stessens, J. Dujardin, P. Herdewijn, P. Büscher. Project co-ordination: A. Solari. Sample collection: I. Zulantay, W. Apt. Project co-ordinator: P. Büscher.