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Research Article

Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening

  • Maha-Hamadien Abdulla equal contributor,

    equal contributor Contributed equally to this work with: Maha-Hamadien Abdulla, Debbie S. Ruelas

    Affiliation: Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences (QB3), University of California, San Francisco, California, United States of America

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  • Debbie S. Ruelas equal contributor,

    equal contributor Contributed equally to this work with: Maha-Hamadien Abdulla, Debbie S. Ruelas

    Affiliation: Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences (QB3), University of California, San Francisco, California, United States of America

    X
  • Brian Wolff,

    Affiliation: Small Molecule Discovery Center, California Institute for Quantitative Biosciences (QB3), University of California, San Francisco, California, United States of America

    X
  • June Snedecor,

    Affiliation: Small Molecule Discovery Center, California Institute for Quantitative Biosciences (QB3), University of California, San Francisco, California, United States of America

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  • Kee-Chong Lim,

    Affiliation: Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences (QB3), University of California, San Francisco, California, United States of America

    X
  • Fengyun Xu,

    Affiliation: Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences (QB3), University of California, San Francisco, California, United States of America

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  • Adam R. Renslo,

    Affiliation: Small Molecule Discovery Center, California Institute for Quantitative Biosciences (QB3), University of California, San Francisco, California, United States of America

    X
  • Janice Williams,

    Affiliation: Small Molecule Discovery Center, California Institute for Quantitative Biosciences (QB3), University of California, San Francisco, California, United States of America

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  • James H. McKerrow,

    Affiliation: Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences (QB3), University of California, San Francisco, California, United States of America

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  • Conor R. Caffrey mail

    caffrey@cgl.ucsf.edu

    Affiliation: Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences (QB3), University of California, San Francisco, California, United States of America

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  • Published: July 14, 2009
  • DOI: 10.1371/journal.pntd.0000478

About the Authors

Maha-Hamadien Abdulla, Debbie S. Ruelas, Kee-Chong Lim, Fengyun Xu, James H. McKerrow, Conor R. Caffrey
Sandler Center for Basic Research in Parasitic Diseases, California Institute for Quantitative Biosciences (QB3), University of California, San Francisco, California, United States of America
Brian Wolff, June Snedecor, Adam R. Renslo, Janice Williams
Small Molecule Discovery Center, California Institute for Quantitative Biosciences (QB3), University of California, San Francisco, California, United States of America

Corresponding Author

Email: caffrey@cgl.ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CRC. Performed the experiments: MHA DSR BW JS KCL FX CRC. Analyzed the data: MHA DSR BW JS KCL FX ARR JW JHM CRC. Contributed reagents/materials/analysis tools: MHA DSR BW JS KCL FX ARR JW JHM CRC. Wrote the paper: MHA DSR BW ARR JW JHM CRC.