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Research Article

Local Suppression of T Cell Responses by Arginase-Induced L-Arginine Depletion in Nonhealing Leishmaniasis

  • Manuel Modolell,

    Affiliation: Department of Cellular Immunology, Max-Planck-Institute for Immunobiology, Freiburg, Germany

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  • Beak-San Choi,

    Affiliation: Department of Immunology, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Robert O. Ryan,

    Affiliation: Lipid Biology in Health and Disease Research Group, Children's Hospital Oakland Research Institute, Oakland, California, United States of America

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  • Maggie Hancock,

    Affiliation: Imperial College Healthcare NHS Trust, Chelsea and Westminster Hospital, London, United Kingdom

    X
  • Richard G. Titus,

    Affiliation: Microbiology, Immunology, and Pathology Department, Colorado State University, Fort Collins, Colorado, United States of America

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  • Tamrat Abebe,

    Affiliation: Department of Microbiology, Parasitology and Immunology, University of Addis Ababa, Addis Ababa, Ethiopia

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  • Asrat Hailu,

    Affiliation: Department of Microbiology, Parasitology and Immunology, University of Addis Ababa, Addis Ababa, Ethiopia

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  • Ingrid Müller,

    Affiliation: Department of Immunology, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Matthew E. Rogers,

    Affiliation: Department of Immunology, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Charles R. M. Bangham,

    Affiliation: Department of Immunology, Faculty of Medicine, Imperial College London, London, United Kingdom

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  • Markus Munder,

    Affiliation: Department of Hematology, Oncology, and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany

    X
  • Pascale Kropf mail

    p.kropf@mperial.ac.uk

    Affiliation: Department of Immunology, Faculty of Medicine, Imperial College London, London, United Kingdom

    X
  • Published: July 14, 2009
  • DOI: 10.1371/journal.pntd.0000480

About the Authors

Manuel Modolell
Department of Cellular Immunology, Max-Planck-Institute for Immunobiology, Freiburg, Germany
Beak-San Choi, Ingrid Müller, Matthew E. Rogers, Charles R. M. Bangham, Pascale Kropf
Department of Immunology, Faculty of Medicine, Imperial College London, London, United Kingdom
Robert O. Ryan
Lipid Biology in Health and Disease Research Group, Children's Hospital Oakland Research Institute, Oakland, California, United States of America
Maggie Hancock
Imperial College Healthcare NHS Trust, Chelsea and Westminster Hospital, London, United Kingdom
Richard G. Titus
Microbiology, Immunology, and Pathology Department, Colorado State University, Fort Collins, Colorado, United States of America
Tamrat Abebe, Asrat Hailu
Department of Microbiology, Parasitology and Immunology, University of Addis Ababa, Addis Ababa, Ethiopia
Markus Munder
Department of Hematology, Oncology, and Rheumatology, University Hospital Heidelberg, Heidelberg, Germany

Corresponding Author

Email: p.kropf@mperial.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MM MM PK. Performed the experiments: BSC MH PK. Analyzed the data: MM BSC RR RGT TA AH IM MER CRMB MM PK. Contributed reagents/materials/analysis tools: RR RGT. Wrote the paper: MM PK.