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Research Article

Bioluminescent Imaging of Trypanosoma brucei Shows Preferential Testis Dissemination Which May Hamper Drug Efficacy in Sleeping Sickness

  • Filip Claes mail,

    fclaes@itg.be

    Affiliations: Institute of Tropical Medicine Antwerp, Department of Parasitology, Antwerp, Belgium, Katholieke Universiteit Leuven, Deptartment of Biosystems, Leuven, Belgium

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  • Suman K. Vodnala,

    Affiliation: Karolinska Institute, Microbiology and Tumorbiology Center, Stockholm, Sweden

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  • Nick van Reet,

    Affiliation: Institute of Tropical Medicine Antwerp, Department of Parasitology, Antwerp, Belgium

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  • Nathalie Boucher,

    Affiliation: Laboratoire de Microbiologie Cellulaire et Moléculaire et Pathogénicité UMR/CNRS-5234, Université Victor Segalen Bordeaux II, Bordeaux, France

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  • Hilda Lunden-Miguel,

    Affiliation: Karolinska Institute, Microbiology and Tumorbiology Center, Stockholm, Sweden

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  • Theo Baltz,

    Affiliation: Laboratoire de Microbiologie Cellulaire et Moléculaire et Pathogénicité UMR/CNRS-5234, Université Victor Segalen Bordeaux II, Bordeaux, France

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  • Bruno Maria Goddeeris,

    Affiliation: Katholieke Universiteit Leuven, Deptartment of Biosystems, Leuven, Belgium

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  • Philippe Büscher,

    Affiliation: Institute of Tropical Medicine Antwerp, Department of Parasitology, Antwerp, Belgium

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  • Martin E. Rottenberg

    Affiliation: Karolinska Institute, Microbiology and Tumorbiology Center, Stockholm, Sweden

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  • Published: July 21, 2009
  • DOI: 10.1371/journal.pntd.0000486

About the Authors

Filip Claes, Nick van Reet, Philippe Büscher
Institute of Tropical Medicine Antwerp, Department of Parasitology, Antwerp, Belgium
Filip Claes, Bruno Maria Goddeeris
Katholieke Universiteit Leuven, Deptartment of Biosystems, Leuven, Belgium
Suman K. Vodnala, Hilda Lunden-Miguel, Martin E. Rottenberg
Karolinska Institute, Microbiology and Tumorbiology Center, Stockholm, Sweden
Nathalie Boucher, Theo Baltz
Laboratoire de Microbiologie Cellulaire et Moléculaire et Pathogénicité UMR/CNRS-5234, Université Victor Segalen Bordeaux II, Bordeaux, France

Corresponding Author

Email: fclaes@itg.be

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: FC BMG PB MER. Performed the experiments: FC SKV NVR NB HLM. Analyzed the data: FC SKV NB TB BMG PB MER. Contributed reagents/materials/analysis tools: MER. Wrote the paper: FC.