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Research Article

Attenuation of Toll-Like Receptor Expression and Function in Latent Tuberculosis by Coexistent Filarial Infection with Restoration Following Antifilarial Chemotherapy

  • Subash Babu mail,

    sbabu@mail.nih.gov

    Affiliations: National Institutes of Health—International Center for Excellence in Research, Chennai, India, Science Applications International Corporation (SAIC)-Frederick, National Cancer Institute (NCI)–Frederick, Frederick, Maryland, United States of America

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  • Sajid Q. Bhat,

    Affiliation: National Institutes of Health—International Center for Excellence in Research, Chennai, India

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  • N. Pavan Kumar,

    Affiliation: National Institutes of Health—International Center for Excellence in Research, Chennai, India

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  • R. Anuradha,

    Affiliation: National Institutes of Health—International Center for Excellence in Research, Chennai, India

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  • Paul Kumaran,

    Affiliation: Tuberculosis Research Center, Chennai, India

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  • P. G. Gopi,

    Affiliation: Tuberculosis Research Center, Chennai, India

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  • C. Kolappan,

    Affiliation: Tuberculosis Research Center, Chennai, India

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  • V. Kumaraswami,

    Affiliation: Tuberculosis Research Center, Chennai, India

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  • Thomas B. Nutman

    Affiliation: Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: July 28, 2009
  • DOI: 10.1371/journal.pntd.0000489

About the Authors

Subash Babu, Sajid Q. Bhat, N. Pavan Kumar, R. Anuradha
National Institutes of Health—International Center for Excellence in Research, Chennai, India
Subash Babu
Science Applications International Corporation (SAIC)-Frederick, National Cancer Institute (NCI)–Frederick, Frederick, Maryland, United States of America
Paul Kumaran, P. G. Gopi, C. Kolappan, V. Kumaraswami
Tuberculosis Research Center, Chennai, India
Thomas B. Nutman
Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

Corresponding Author

Email: sbabu@mail.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SB VK TBN. Performed the experiments: SB SQB NPK RA. Analyzed the data: SB SQB NPK RA. Contributed reagents/materials/analysis tools: PK PGG CK VK. Wrote the paper: SB TBN.