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Research Article

Murine Models for Trypanosoma brucei gambiense Disease Progression—From Silent to Chronic Infections and Early Brain Tropism

  • Christiane Giroud equal contributor,

    equal contributor Contributed equally to this work with: Christiane Giroud, Florence Ottones, Virginie Coustou

    Affiliation: UMR 5234, Centre National de Recherche Scientifique, IFR66, Université Bordeaux 2, Bordeaux, France

    X
  • Florence Ottones equal contributor,

    equal contributor Contributed equally to this work with: Christiane Giroud, Florence Ottones, Virginie Coustou

    Affiliation: UMR 5234, Centre National de Recherche Scientifique, IFR66, Université Bordeaux 2, Bordeaux, France

    X
  • Virginie Coustou equal contributor,

    equal contributor Contributed equally to this work with: Christiane Giroud, Florence Ottones, Virginie Coustou

    Affiliation: UMR 5234, Centre National de Recherche Scientifique, IFR66, Université Bordeaux 2, Bordeaux, France

    X
  • Denis Dacheux,

    Affiliation: UMR 5234, Centre National de Recherche Scientifique, IFR66, Université Bordeaux 2, Bordeaux, France

    X
  • Nicolas Biteau,

    Affiliation: UMR 5234, Centre National de Recherche Scientifique, IFR66, Université Bordeaux 2, Bordeaux, France

    X
  • Benjamin Miezan,

    Affiliation: Projet de recherches cliniques sur la trypanosomiase (PRCT), Daloa, Ivory Coast

    X
  • Nick Van Reet,

    Affiliation: Institute of Tropical Medicine Antwerp, Department of Parasitology, Antwerp, Belgium

    X
  • Mark Carrington,

    Affiliation: Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

    X
  • Felix Doua,

    Affiliation: Projet de recherches cliniques sur la trypanosomiase (PRCT), Daloa, Ivory Coast

    X
  • Théo Baltz mail

    theo.baltz@u-bordeaux2.fr

    Affiliation: UMR 5234, Centre National de Recherche Scientifique, IFR66, Université Bordeaux 2, Bordeaux, France

    X
  • Published: September 01, 2009
  • DOI: 10.1371/journal.pntd.0000509

About the Authors

Christiane Giroud, Florence Ottones, Virginie Coustou, Denis Dacheux, Nicolas Biteau, Théo Baltz
UMR 5234, Centre National de Recherche Scientifique, IFR66, Université Bordeaux 2, Bordeaux, France
Benjamin Miezan, Felix Doua
Projet de recherches cliniques sur la trypanosomiase (PRCT), Daloa, Ivory Coast
Nick Van Reet
Institute of Tropical Medicine Antwerp, Department of Parasitology, Antwerp, Belgium
Mark Carrington
Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom

Corresponding Author

Email: theo.baltz@u-bordeaux2.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CG FO VC DD NB BM NVR MC FD TB. Performed the experiments: CG FO VC DD NB BM NVR. Analyzed the data: CG FO VC DD NB BM TB. Wrote the paper: FO NB TB. Critically reviewed the paper: VC MC. Patient recruitment and examinations: FD.