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Research Article

Immunogenic Salivary Proteins of Triatoma infestans: Development of a Recombinant Antigen for the Detection of Low-Level Infestation of Triatomines

  • Alexandra Schwarz mail,

    alexandraschwarz@arcor.de

    Affiliations: School of Biological Sciences, Zoology Building, University of Aberdeen, Aberdeen, United Kingdom, Group Zoology/Parasitology, Ruhr-Universität Bochum, Bochum, Germany

    X
  • Stefan Helling,

    Affiliation: Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany

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  • Nicolas Collin,

    Affiliation: Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

    X
  • Clarissa R. Teixeira,

    Affiliation: Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

    X
  • Nora Medrano-Mercado,

    Affiliation: Laboratory of Chagas Disease and Immunoparasitology, Biology Department–Facultad de Ciencias y Tecnología, Universidad Mayor de San Simón, Cochabamba, Bolivia

    X
  • Jen C. C. Hume,

    Affiliation: International Studies of Malaria and Entomology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

    X
  • Teresa C. Assumpção,

    Affiliation: Laboratory of Host-Parasite Interface, University of Brasilia, Brasilia-DF, Brazil

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  • Katrin Marcus,

    Affiliation: Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany

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  • Christian Stephan,

    Affiliation: Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany

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  • Helmut E. Meyer,

    Affiliation: Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany

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  • José M. C. Ribeiro,

    Affiliation: Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

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  • Peter F. Billingsley,

    Affiliations: School of Biological Sciences, Zoology Building, University of Aberdeen, Aberdeen, United Kingdom, Sanaria, Rockville, Maryland, United States of America

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  • Jesus G. Valenzuela ,

    Affiliation: Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

    These authors are joint senior authors on this work.

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  • Jeremy M. Sternberg ,

    Affiliation: School of Biological Sciences, Zoology Building, University of Aberdeen, Aberdeen, United Kingdom

    These authors are joint senior authors on this work.

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  • Günter A. Schaub

    Affiliation: Group Zoology/Parasitology, Ruhr-Universität Bochum, Bochum, Germany

    These authors are joint senior authors on this work.

    X
  • Published: October 20, 2009
  • DOI: 10.1371/journal.pntd.0000532

About the Authors

Alexandra Schwarz, Peter F. Billingsley, Jeremy M. Sternberg
School of Biological Sciences, Zoology Building, University of Aberdeen, Aberdeen, United Kingdom
Alexandra Schwarz, Günter A. Schaub
Group Zoology/Parasitology, Ruhr-Universität Bochum, Bochum, Germany
Stefan Helling, Katrin Marcus, Christian Stephan, Helmut E. Meyer
Medizinisches Proteom-Center, Ruhr-Universität Bochum, Bochum, Germany
Nicolas Collin, Clarissa R. Teixeira, José M. C. Ribeiro, Jesus G. Valenzuela
Vector Molecular Biology Unit, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
Nora Medrano-Mercado
Laboratory of Chagas Disease and Immunoparasitology, Biology Department–Facultad de Ciencias y Tecnología, Universidad Mayor de San Simón, Cochabamba, Bolivia
Jen C. C. Hume
International Studies of Malaria and Entomology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
Teresa C. Assumpção
Laboratory of Host-Parasite Interface, University of Brasilia, Brasilia-DF, Brazil
Peter F. Billingsley
Sanaria, Rockville, Maryland, United States of America

Corresponding Author

Email: alexandraschwarz@arcor.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AS SH NC CRT PFB JGV JMS GAS. Performed the experiments: AS SH NC CRT NMM JCCH. Analyzed the data: AS SH NC CS JMS. Contributed reagents/materials/analysis tools: JCCH TCA KM HEM JMCR JGV JMS GAS. Wrote the paper: AS JMS GAS.