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Research Article

NMR Analysis of the Dynamic Exchange of the NS2B Cofactor between Open and Closed Conformations of the West Nile Virus NS2B-NS3 Protease

  • Xun-Cheng Su equal contributor,

    equal contributor Contributed equally to this work with: Xun-Cheng Su, Kiyoshi Ozawa

    Affiliation: Australian National University, Research School of Chemistry, Canberra, Australia

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  • Kiyoshi Ozawa equal contributor,

    equal contributor Contributed equally to this work with: Xun-Cheng Su, Kiyoshi Ozawa

    Affiliation: Australian National University, Research School of Chemistry, Canberra, Australia

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  • Ruhu Qi,

    Affiliation: Australian National University, Research School of Chemistry, Canberra, Australia

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  • Subhash G. Vasudevan,

    Affiliation: Novartis Institute for Tropical Diseases, Chromos, Singapore

    Current address: Program in Emerging Infectious Diseases, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857

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  • Siew P. Lim,

    Affiliation: Novartis Institute for Tropical Diseases, Chromos, Singapore

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  • Gottfried Otting mail

    go@rsc.anu.edu.au

    Affiliation: Australian National University, Research School of Chemistry, Canberra, Australia

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  • Published: December 08, 2009
  • DOI: 10.1371/journal.pntd.0000561

About the Authors

Xun-Cheng Su, Kiyoshi Ozawa, Ruhu Qi, Gottfried Otting
Australian National University, Research School of Chemistry, Canberra, Australia
Subhash G. Vasudevan, Siew P. Lim
Novartis Institute for Tropical Diseases, Chromos, Singapore

Corresponding Author

Email: go@rsc.anu.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: XCS KO SGV GO. Performed the experiments: XCS KO RQ. Analyzed the data: XCS GO. Contributed reagents/materials/analysis tools: KO RQ SGV SPL. Wrote the paper: XCS SGV GO.