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Research Article

A Randomized Controlled Trial of Local Heat Therapy Versus Intravenous Sodium Stibogluconate for the Treatment of Cutaneous Leishmania major Infection

  • Naomi E. Aronson mail,

    Naomi.aronson@us.army.mil

    Affiliations: Infectious Diseases Division, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Infectious Diseases Service, Walter Reed Army Medical Center, Washington (D. C.), United States of America

    X
  • Glenn W. Wortmann,

    Affiliations: Infectious Diseases Division, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Infectious Diseases Service, Walter Reed Army Medical Center, Washington (D. C.), United States of America

    X
  • William R. Byrne,

    Affiliation: Infectious Diseases Service, Walter Reed Army Medical Center, Washington (D. C.), United States of America

    X
  • Robin S. Howard,

    Affiliation: Department of Clinical Investigation, Walter Reed Army Medical Center, Washington (D. C.), United States of America

    X
  • Wendy B. Bernstein,

    Affiliations: Infectious Diseases Division, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Department of Retrovirology, Walter Reed Army Institute of Research, Rockville, Maryland, United States of America

    X
  • Mary A. Marovich,

    Affiliations: Infectious Diseases Division, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Department of Retrovirology, Walter Reed Army Institute of Research, Rockville, Maryland, United States of America

    X
  • Mark E. Polhemus,

    Affiliations: Infectious Diseases Division, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Infectious Diseases Service, Walter Reed Army Medical Center, Washington (D. C.), United States of America

    X
  • In-Kyu Yoon,

    Affiliation: Department of Clinical Trials, Walter Reed Army Institute of Research, Silver Springs, Maryland, United States of America

    X
  • Kelly A. Hummer,

    Affiliations: Infectious Diseases Service, Walter Reed Army Medical Center, Washington (D. C.), United States of America, Clinical Research Management, Hinckley, Ohio, United States of America

    X
  • Robert A. Gasser Jr,

    Affiliations: Infectious Diseases Division, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Infectious Diseases Service, Walter Reed Army Medical Center, Washington (D. C.), United States of America

    X
  • Charles N. Oster,

    Affiliations: Infectious Diseases Division, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America, Infectious Diseases Service, Walter Reed Army Medical Center, Washington (D. C.), United States of America

    X
  • Paul M. Benson

    Affiliation: Infectious Diseases Service, Walter Reed Army Medical Center, Washington (D. C.), United States of America

    X
  • Published: March 09, 2010
  • DOI: 10.1371/journal.pntd.0000628

About the Authors

Naomi E. Aronson, Glenn W. Wortmann, Wendy B. Bernstein, Mary A. Marovich, Mark E. Polhemus, Robert A. Gasser Jr, Charles N. Oster
Infectious Diseases Division, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
Naomi E. Aronson, Glenn W. Wortmann, William R. Byrne, Mark E. Polhemus, Kelly A. Hummer, Robert A. Gasser Jr, Charles N. Oster, Paul M. Benson
Infectious Diseases Service, Walter Reed Army Medical Center, Washington (D. C.), United States of America
Robin S. Howard
Department of Clinical Investigation, Walter Reed Army Medical Center, Washington (D. C.), United States of America
Wendy B. Bernstein, Mary A. Marovich
Department of Retrovirology, Walter Reed Army Institute of Research, Rockville, Maryland, United States of America
In-Kyu Yoon
Department of Clinical Trials, Walter Reed Army Institute of Research, Silver Springs, Maryland, United States of America
Kelly A. Hummer
Clinical Research Management, Hinckley, Ohio, United States of America

Corresponding Author

Email: Naomi.aronson@us.army.mil

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NEA RSH PMB. Performed the experiments: NEA GWW WRB WBB MAM MEP IKY KAH PMB. Analyzed the data: NEA RSH WBB RAG CNO PMB. Contributed reagents/materials/analysis tools: GWW MAM KAH RAG CNO PMB. Wrote the paper: NEA RSH MAM. Developed the PCR for rapid diagnosis: GWW. Critically reviewed the manuscript: GWW WRB MEP IKY KAH RAG CNO PMB. Critically reviewed draft manuscript: WBB.