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Research Article

Influence of Exposure History on the Immunology and Development of Resistance to Human Schistosomiasis Mansoni

  • Carla L. Black mail,

    blackc@uga.edu

    Affiliation: Center for Tropical and Emerging Global Diseases and Department of Microbiology, University of Georgia, Athens, Georgia, United States of America

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  • Pauline N. M. Mwinzi,

    Affiliation: Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya

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  • Erick M. O. Muok,

    Affiliation: Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya

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  • Bernard Abudho,

    Affiliation: Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya

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  • Colin M. Fitzsimmons,

    Affiliation: Department of Pathology, University of Cambridge, Cambridge, United Kingdom

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  • David W. Dunne,

    Affiliation: Department of Pathology, University of Cambridge, Cambridge, United Kingdom

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  • Diana M. S. Karanja,

    Affiliation: Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya

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  • W. Evan Secor,

    Affiliation: Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

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  • Daniel G. Colley

    Affiliation: Center for Tropical and Emerging Global Diseases and Department of Microbiology, University of Georgia, Athens, Georgia, United States of America

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  • Published: March 23, 2010
  • DOI: 10.1371/journal.pntd.0000637

About the Authors

Carla L. Black, Daniel G. Colley
Center for Tropical and Emerging Global Diseases and Department of Microbiology, University of Georgia, Athens, Georgia, United States of America
Pauline N. M. Mwinzi, Erick M. O. Muok, Bernard Abudho, Diana M. S. Karanja
Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya
Colin M. Fitzsimmons, David W. Dunne
Department of Pathology, University of Cambridge, Cambridge, United Kingdom
W. Evan Secor
Division of Parasitic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

Corresponding Author

Email: blackc@uga.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DMSK WES DGC. Performed the experiments: PNMM EMOM BA. Analyzed the data: CLB. Contributed reagents/materials/analysis tools: CMF DWD WES. Wrote the paper: CLB. Organized and implemented longitudinal field work: PNMM EMOM BA DMSK.