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Research Article

Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole

  • Chiung-Kuang Chen,

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

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  • Siegfried S. F. Leung,

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

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  • Christophe Guilbert,

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

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  • Matthew P. Jacobson,

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

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  • James H. McKerrow,

    Affiliation: Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, California, United States of America

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  • Larissa M. Podust mail

    larissa.podust@ucsf.edu

    Affiliation: Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America

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  • Published: April 06, 2010
  • DOI: 10.1371/journal.pntd.0000651

About the Authors

Chiung-Kuang Chen, Siegfried S. F. Leung, Christophe Guilbert, Matthew P. Jacobson, Larissa M. Podust
Department of Pharmaceutical Chemistry, University of California, San Francisco, California, United States of America
James H. McKerrow
Sandler Center for Basic Research in Parasitic Diseases, University of California, San Francisco, California, United States of America

Corresponding Author

Email: larissa.podust@ucsf.edu

Competing Interests

Matthew P. Jacobson is a consultant to Schrodinger, LLC.

Author Contributions

Conceived and designed the experiments: MPJ LMP. Performed the experiments: CKC SSFL LMP. Analyzed the data: CKC SSFL CG LMP. Contributed reagents/materials/analysis tools: CG MPJ JHM LMP. Wrote the paper: JHM LMP.