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Research Article

A Target-Based High Throughput Screen Yields Trypanosoma brucei Hexokinase Small Molecule Inhibitors with Antiparasitic Activity

  • Elizabeth R. Sharlow,

    Affiliations: University of Pittsburgh Drug Discovery Institute and Pittsburgh Molecular Libraries Screening Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Todd A. Lyda,

    Affiliation: Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America

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  • Heidi C. Dodson,

    Affiliation: Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America

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  • Gabriela Mustata,

    Affiliation: Department of Computational Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Meredith T. Morris,

    Affiliation: Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America

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  • Stephanie S. Leimgruber,

    Affiliations: University of Pittsburgh Drug Discovery Institute and Pittsburgh Molecular Libraries Screening Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • Kuo-Hsiung Lee,

    Affiliation: Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Yoshiki Kashiwada,

    Affiliation: Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan

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  • David Close,

    Affiliations: University of Pittsburgh Drug Discovery Institute and Pittsburgh Molecular Libraries Screening Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • John S. Lazo,

    Affiliations: University of Pittsburgh Drug Discovery Institute and Pittsburgh Molecular Libraries Screening Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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  • James C. Morris mail

    jmorri2@clemson

    Affiliation: Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America

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  • Published: April 13, 2010
  • DOI: 10.1371/journal.pntd.0000659

About the Authors

Elizabeth R. Sharlow, Stephanie S. Leimgruber, David Close, John S. Lazo
University of Pittsburgh Drug Discovery Institute and Pittsburgh Molecular Libraries Screening Center, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Elizabeth R. Sharlow, Stephanie S. Leimgruber, David Close, John S. Lazo
Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Todd A. Lyda, Heidi C. Dodson, Meredith T. Morris, James C. Morris
Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina, United States of America
Gabriela Mustata
Department of Computational Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
Kuo-Hsiung Lee
Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, United States of America
Yoshiki Kashiwada
Graduate School of Pharmaceutical Sciences, University of Tokushima, Tokushima, Japan

Corresponding Author

Email: jmorri2@clemson

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ERS TAL HCD GM MTM SSL JSL JCM. Performed the experiments: ERS TAL HCD GM SSL DC. Analyzed the data: ERS TAL HCD GM SSL DC JSL JCM. Contributed reagents/materials/analysis tools: ERS TAL GM KHL YK JCM. Wrote the paper: ERS TAL GM MTM JSL JCM.