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Research Article

Macrofilaricidal Activity after Doxycycline Only Treatment of Onchocerca volvulus in an Area of Loa loa Co-Endemicity: A Randomized Controlled Trial

  • Joseph D. Turner,

    Affiliation: Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

    Current address: Schistosome Research Group, Centre for Immunology and Infection, Department of Biology and Hull York Medical School, University of York, York, United Kingdom

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  • Nicholas Tendongfor,

    Affiliations: Department of Life Sciences, Faculty of Science, University of Buea, Buea, Cameroon, Research Foundation in Tropical Diseases and Environment (REFOTDE), Buea, Cameroon

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  • Mathias Esum,

    Affiliations: Department of Life Sciences, Faculty of Science, University of Buea, Buea, Cameroon, Research Foundation in Tropical Diseases and Environment (REFOTDE), Buea, Cameroon

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  • Kelly L. Johnston,

    Affiliation: Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

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  • R. Stuart Langley,

    Affiliation: Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

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  • Louise Ford,

    Affiliation: Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

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  • Brian Faragher,

    Affiliation: Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

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  • Sabine Specht,

    Affiliation: Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn, Bonn, Germany

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  • Sabine Mand,

    Affiliation: Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn, Bonn, Germany

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  • Achim Hoerauf,

    Affiliation: Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn, Bonn, Germany

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  • Peter Enyong,

    Affiliation: Tropical Medicine Research Station, Kumba, Cameroon

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  • Samuel Wanji,

    Affiliations: Department of Life Sciences, Faculty of Science, University of Buea, Buea, Cameroon, Research Foundation in Tropical Diseases and Environment (REFOTDE), Buea, Cameroon

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  • Mark J. Taylor mail

    mark.taylor@liverpool.ac.uk

    Affiliation: Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom

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  • Published: April 13, 2010
  • DOI: 10.1371/journal.pntd.0000660

About the Authors

Joseph D. Turner, Kelly L. Johnston, R. Stuart Langley, Louise Ford, Brian Faragher, Mark J. Taylor
Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
Nicholas Tendongfor, Mathias Esum, Samuel Wanji
Department of Life Sciences, Faculty of Science, University of Buea, Buea, Cameroon
Nicholas Tendongfor, Mathias Esum, Samuel Wanji
Research Foundation in Tropical Diseases and Environment (REFOTDE), Buea, Cameroon
Sabine Specht, Sabine Mand, Achim Hoerauf
Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn, Bonn, Germany
Peter Enyong
Tropical Medicine Research Station, Kumba, Cameroon

Corresponding Author

Email: mark.taylor@liverpool.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AH MJT. Performed the experiments: JDT NT ME KLJ RSL LF SS SM PE SW. Analyzed the data: JDT NT ME KLJ RSL LF BF SS SM PE SW MJT. Contributed reagents/materials/analysis tools: MJT. Wrote the paper: JDT MJT.