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Research Article

A Non Mouse-Adapted Dengue Virus Strain as a New Model of Severe Dengue Infection in AG129 Mice

  • Grace K. Tan,

    Affiliation: Department of Microbiology, Immunology Programme, National University of Singapore, Singapore, Singapore

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  • Jowin K. W. Ng,

    Affiliation: Department of Microbiology, Immunology Programme, National University of Singapore, Singapore, Singapore

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  • Scott L. Trasti,

    Affiliation: Comparative Medicine Centre, National University of Singapore, Singapore, Singapore

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  • Wouter Schul,

    Affiliation: Novartis Institute for Tropical Diseases (NITD), Singapore, Singapore

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  • George Yip,

    Affiliation: Department of Anatomy, National University of Singapore, Singapore, Singapore

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  • Sylvie Alonso mail

    micas@nus.edu.sg

    Affiliation: Department of Microbiology, Immunology Programme, National University of Singapore, Singapore, Singapore

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  • Published: April 27, 2010
  • DOI: 10.1371/journal.pntd.0000672

About the Authors

Grace K. Tan, Jowin K. W. Ng, Sylvie Alonso
Department of Microbiology, Immunology Programme, National University of Singapore, Singapore, Singapore
Scott L. Trasti
Comparative Medicine Centre, National University of Singapore, Singapore, Singapore
Wouter Schul
Novartis Institute for Tropical Diseases (NITD), Singapore, Singapore
George Yip
Department of Anatomy, National University of Singapore, Singapore, Singapore

Corresponding Author

Email: micas@nus.edu.sg

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GKT SA. Performed the experiments: GKT JKWN. Analyzed the data: GKT SA. Contributed reagents/materials/analysis tools: SLT WS GY. Wrote the paper: GKT SA.