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Research Article

Large Scale Immune Profiling of Infected Humans and Goats Reveals Differential Recognition of Brucella melitensis Antigens

  • Li Liang,

    Affiliation: Division of Infectious Diseases, Department of Medicine, University of California Irvine, Irvine, California, United States of America

    X
  • Diana Leng,

    Affiliation: Alexander von Humboldt Institute of Tropical Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru

    X
  • Chad Burk,

    Affiliation: Division of Infectious Diseases, Department of Medicine, University of California Irvine, Irvine, California, United States of America

    X
  • Rie Nakajima-Sasaki,

    Affiliation: Division of Infectious Diseases, Department of Medicine, University of California Irvine, Irvine, California, United States of America

    X
  • Matthew A. Kayala,

    Affiliations: Department of Computer Science, University of California Irvine, Irvine, California, United States of America, Institute for Genomics and Bioinformatics, University of California Irvine, Irvine, California, United States of America

    X
  • Vidya L. Atluri,

    Affiliation: Department of Medical Microbiology and Immunology, University of California Davis, Davis, California, United States of America

    X
  • Jozelyn Pablo,

    Affiliation: Division of Infectious Diseases, Department of Medicine, University of California Irvine, Irvine, California, United States of America

    X
  • Berkay Unal,

    Affiliation: Division of Infectious Diseases, Department of Medicine, University of California Irvine, Irvine, California, United States of America

    X
  • Thomas A. Ficht,

    Affiliation: Department of Veterinary Pathobiology, Texas A&M University and Texas Agricultural Experiment Station, College Station, Texas, United States of America

    X
  • Eduardo Gotuzzo,

    Affiliation: Alexander von Humboldt Institute of Tropical Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru

    X
  • Mayuko Saito,

    Affiliation: Asociacion Benefica PRISMA, Lima, Peru

    X
  • W. John W. Morrow,

    Affiliation: Antigen Discovery, Inc., Irvine, California, United States of America

    X
  • Xiaowu Liang,

    Affiliation: Antigen Discovery, Inc., Irvine, California, United States of America

    X
  • Pierre Baldi,

    Affiliations: Department of Computer Science, University of California Irvine, Irvine, California, United States of America, Institute for Genomics and Bioinformatics, University of California Irvine, Irvine, California, United States of America, Department of Biological Chemistry, University of California Irvine, Irvine, California, United States of America

    X
  • Robert H. Gilman,

    Affiliation: Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America

    X
  • Joseph M. Vinetz mail,

    jvinetz@ucsd.edu (JMV); rmtsolis@ucdavis.edu (RMT); pfelgner@uci.edu (PLF)

    Affiliation: Division of Infectious Diseases, University of California San Diego School of Medicine, La Jolla, California, United States of America

    X
  • Renée M. Tsolis mail,

    jvinetz@ucsd.edu (JMV); rmtsolis@ucdavis.edu (RMT); pfelgner@uci.edu (PLF)

    Affiliation: Department of Medical Microbiology and Immunology, University of California Davis, Davis, California, United States of America

    X
  • Philip L. Felgner mail

    jvinetz@ucsd.edu (JMV); rmtsolis@ucdavis.edu (RMT); pfelgner@uci.edu (PLF)

    Affiliations: Division of Infectious Diseases, Department of Medicine, University of California Irvine, Irvine, California, United States of America, Institute for Genomics and Bioinformatics, University of California Irvine, Irvine, California, United States of America, Antigen Discovery, Inc., Irvine, California, United States of America

    X
  • Published: May 04, 2010
  • DOI: 10.1371/journal.pntd.0000673

About the Authors

Li Liang, Chad Burk, Rie Nakajima-Sasaki, Jozelyn Pablo, Berkay Unal, Philip L. Felgner
Division of Infectious Diseases, Department of Medicine, University of California Irvine, Irvine, California, United States of America
Diana Leng, Eduardo Gotuzzo
Alexander von Humboldt Institute of Tropical Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru
Matthew A. Kayala, Pierre Baldi
Department of Computer Science, University of California Irvine, Irvine, California, United States of America
Matthew A. Kayala, Pierre Baldi, Philip L. Felgner
Institute for Genomics and Bioinformatics, University of California Irvine, Irvine, California, United States of America
Vidya L. Atluri, Renée M. Tsolis
Department of Medical Microbiology and Immunology, University of California Davis, Davis, California, United States of America
Thomas A. Ficht
Department of Veterinary Pathobiology, Texas A&M University and Texas Agricultural Experiment Station, College Station, Texas, United States of America
Mayuko Saito
Asociacion Benefica PRISMA, Lima, Peru
W. John W. Morrow, Xiaowu Liang, Philip L. Felgner
Antigen Discovery, Inc., Irvine, California, United States of America
Pierre Baldi
Department of Biological Chemistry, University of California Irvine, Irvine, California, United States of America
Robert H. Gilman
Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America
Joseph M. Vinetz
Division of Infectious Diseases, University of California San Diego School of Medicine, La Jolla, California, United States of America

Corresponding Authors

Competing Interests

PLF is an inventor on patent applications pertaining to this work and owns stock in a company (Anitigen Discovery Inc.) that has licensed the technology. XL is an inventor on patent applications pertaining to this work and is employed at a company (Anitigen Discovery Inc.) that has licensed the technology. WJWM is employed at company (Anitigen Discovery Inc.) that has licensed technology pertaining to this work.

Author Contributions

Conceived and designed the experiments: LL CB WJWM XL JMV RMT PLF. Performed the experiments: LL DL CB RNS VLA JP BU. Analyzed the data: LL CB MAK PLF. Contributed reagents/materials/analysis tools: DL MAK TAF EG MS PB RHG JMV RMT. Wrote the paper: LL MAK JMV RMT PLF.