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Research Article

Geographical Variation in the Response of Visceral Leishmaniasis to Paromomycin in East Africa: A Multicentre, Open-Label, Randomized Trial

  • Asrat Hailu,

    Affiliation: Addis Ababa University, Addis Ababa, Ethiopia

    X
  • Ahmed Musa,

    Affiliation: Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan

    X
  • Monique Wasunna mail,

    africa@dndi.org

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • Manica Balasegaram,

    Affiliations: Medecins Sans Frontieres-Holland, Amsterdam, The Netherlands, Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland

    X
  • Sisay Yifru,

    Affiliation: Gondar University, Gondar, Ethiopia

    X
  • Getahun Mengistu,

    Affiliation: Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan

    X
  • Zewdu Hurissa,

    Affiliation: Gondar University, Gondar, Ethiopia

    X
  • Workagegnehu Hailu,

    Affiliation: Gondar University, Gondar, Ethiopia

    X
  • Teklu Weldegebreal,

    Affiliation: Arba Minch Hospital, Regional Health Bureau of SNNP state, Arba Minch, Ethiopia

    X
  • Samson Tesfaye,

    Affiliation: Arba Minch Hospital, Regional Health Bureau of SNNP state, Arba Minch, Ethiopia

    X
  • Eyasu Makonnen,

    Affiliation: Addis Ababa University, Addis Ababa, Ethiopia

    X
  • Eltahir Khalil,

    Affiliation: Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan

    X
  • Osama Ahmed,

    Affiliation: Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan

    X
  • Ahmed Fadlalla,

    Affiliation: Faculty of Medicine, Gedaref University, Gedaref, Sudan

    X
  • Ahmed El-Hassan,

    Affiliation: Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan

    X
  • Muzamil Raheem,

    Affiliation: Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan

    X
  • Marius Mueller,

    Affiliation: Medecins Sans Frontieres-Holland, Amsterdam, The Netherlands

    X
  • Yousif Koummuki,

    Affiliation: Medecins Sans Frontieres-Holland, Amsterdam, The Netherlands

    X
  • Juma Rashid,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • Jane Mbui,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • Geoffrey Mucee,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • Simon Njoroge,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

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  • Veronica Manduku,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • Alice Musibi,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • Geoffrey Mutuma,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • Fredrick Kirui,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • Hudson Lodenyo,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • Dedan Mutea,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • George Kirigi,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • Tansy Edwards,

    Affiliation: London School of Hygiene and Tropical Medicine, London, United Kingdom

    X
  • Peter Smith,

    Affiliation: London School of Hygiene and Tropical Medicine, London, United Kingdom

    X
  • Lawrence Muthami,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • Catherine Royce,

    Affiliation: Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland

    X
  • Sally Ellis,

    Affiliation: Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland

    X
  • Moses Alobo,

    Affiliation: Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland

    X
  • Raymond Omollo,

    Affiliation: Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland

    X
  • Josephine Kesusu,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • Rhoda Owiti,

    Affiliation: Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya

    X
  • John Kinuthia,

    Affiliation: Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland

    X
  • for the Leishmaniasis East Africa Platform (LEAP) group
  • Published: October 26, 2010
  • DOI: 10.1371/journal.pntd.0000709

About the Authors

Asrat Hailu, Eyasu Makonnen
Addis Ababa University, Addis Ababa, Ethiopia
Ahmed Musa, Getahun Mengistu, Eltahir Khalil, Osama Ahmed, Ahmed El-Hassan, Muzamil Raheem
Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
Monique Wasunna, Juma Rashid, Jane Mbui, Geoffrey Mucee, Simon Njoroge, Veronica Manduku, Alice Musibi, Geoffrey Mutuma, Fredrick Kirui, Hudson Lodenyo, Dedan Mutea, George Kirigi, Lawrence Muthami, Josephine Kesusu, Rhoda Owiti
Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya
Manica Balasegaram, Marius Mueller, Yousif Koummuki
Medecins Sans Frontieres-Holland, Amsterdam, The Netherlands
Manica Balasegaram, Catherine Royce, Sally Ellis, Moses Alobo, Raymond Omollo, John Kinuthia
Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland
Sisay Yifru, Zewdu Hurissa, Workagegnehu Hailu
Gondar University, Gondar, Ethiopia
Teklu Weldegebreal, Samson Tesfaye
Arba Minch Hospital, Regional Health Bureau of SNNP state, Arba Minch, Ethiopia
Ahmed Fadlalla
Faculty of Medicine, Gedaref University, Gedaref, Sudan
Tansy Edwards, Peter Smith
London School of Hygiene and Tropical Medicine, London, United Kingdom

Corresponding Author

Email: africa@dndi.org

Competing Interests

Manica Balasegaram is employed by DNDi as a Project Manager. Sally Ellis is employed by DNDi as a Clinical Coordinator. Moses Alobo is employed by DNDi as a Clinical Trial Manager. Catherine Royce and John Kinuthia work for DNDi. Marius Mueller and Yousif Koummuki work for MSF.

Author Contributions

Conceived and designed the experiments: M. Wasunna, A. Hailu, A. Musa, M. Balasegaram, E. Makonnen, E. Khalil, A. El-Hassan, J. Rashid, C. Royce. Performed the experiments: M. Wasunna, M. Balasegaram, S. Yifru, G. Mengistu, Z. Hurissa, W. Hailu, T. Weldegebreal, S. Tesfaye, O. Ahmed, A. Fadlalla, M. Raheem, M. Mueller, Y. Koummuki, J. Rashid, J. Mbui, G. Mucee, S. Njoroge, V. Manduku, A. Musibi, G. Mutuma, F. Kirui, H. Lodenyo, D. Mutea, G. Kirigi, J. Kesusu, R. Owiti, J. Kinuthia. Analyzed the data: T. Edwards, P. Smith, L. Muthami, S. Ellis, M. Alobo, R. Omollo. Contributed reagents/materials/analysis tools: M. Wasunna, C. Royce, S. Ellis, M. Alobo. Wrote the paper: M. Wasunna, A. Hailu, A. Musa, M. Balasegaram, T. Edwards, P. Smith, C. Royce.