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Research Article

Assay Strategies for the Discovery and Validation of Therapeutics Targeting Brugia pahangi Hsp90

  • Tony Taldone,

    Affiliation: Department of Molecular Pharmacology and Chemistry, Sloan Kettering Institute, New York, New York, United States of America

    X
  • Victoria Gillan,

    Affiliation: Parasitology Group, Division of Veterinary Infection and Immunity, Institute of Comparative Medicine, University of Glasgow, Glasgow, United Kingdom

    X
  • Weilin Sun,

    Affiliation: Department of Molecular Pharmacology and Chemistry, Sloan Kettering Institute, New York, New York, United States of America

    X
  • Anna Rodina,

    Affiliation: Department of Molecular Pharmacology and Chemistry, Sloan Kettering Institute, New York, New York, United States of America

    X
  • Pallav Patel,

    Affiliation: Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, New York, New York, United States of America

    X
  • Kirsty Maitland,

    Affiliation: Parasitology Group, Division of Veterinary Infection and Immunity, Institute of Comparative Medicine, University of Glasgow, Glasgow, United Kingdom

    X
  • Kerry O'Neill,

    Affiliation: Parasitology Group, Division of Veterinary Infection and Immunity, Institute of Comparative Medicine, University of Glasgow, Glasgow, United Kingdom

    X
  • Gabriela Chiosis mail,

    chiosisg@MSKCC.ORG (GC); e.devaney@vet.gla.ac.uk (ED)

    Affiliation: Department of Molecular Pharmacology and Chemistry, Sloan Kettering Institute, New York, New York, United States of America

    X
  • Eileen Devaney mail

    chiosisg@MSKCC.ORG (GC); e.devaney@vet.gla.ac.uk (ED)

    Affiliation: Parasitology Group, Division of Veterinary Infection and Immunity, Institute of Comparative Medicine, University of Glasgow, Glasgow, United Kingdom

    X
  • Published: June 15, 2010
  • DOI: 10.1371/journal.pntd.0000714

About the Authors

Tony Taldone, Weilin Sun, Anna Rodina, Gabriela Chiosis
Department of Molecular Pharmacology and Chemistry, Sloan Kettering Institute, New York, New York, United States of America
Victoria Gillan, Kirsty Maitland, Kerry O'Neill, Eileen Devaney
Parasitology Group, Division of Veterinary Infection and Immunity, Institute of Comparative Medicine, University of Glasgow, Glasgow, United Kingdom
Pallav Patel
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St. John's University, Jamaica, New York, New York, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GC ED. Performed the experiments: TT VG WS AR PP KM KO. Analyzed the data: TT GC ED. Wrote the paper: TT GC ED.