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Research Article

Structural Optimization and De Novo Design of Dengue Virus Entry Inhibitory Peptides

  • Joshua M. Costin,

    Affiliation: Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, Florida, United States of America

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  • Ekachai Jenwitheesuk,

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

    Current address: National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Klong Luang, Thailand

    X
  • Shee-Mei Lok,

    Affiliation: Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America

    Current address: Program in Emerging Infectious Disease, Duke –NUS Graduate Medical School, and Department of Biological Sciences, National University of Singapore, Singapore, Singapore

    X
  • Elizabeth Hunsperger,

    Affiliation: Dengue Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico

    X
  • Kelly A. Conrads,

    Affiliation: FortéBio, Incorporated, Menlo Park, California, United States of America

    X
  • Krystal A. Fontaine,

    Affiliation: Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, Florida, United States of America

    Current address: Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, United States of America

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  • Craig R. Rees,

    Affiliation: Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, Florida, United States of America

    Current address: School of Public Health, University of Florida, Gainesville, Florida, United States of America

    X
  • Michael G. Rossmann,

    Affiliation: Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America

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  • Sharon Isern,

    Affiliation: Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, Florida, United States of America

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  • Ram Samudrala mail,

    ram@compbio.washington.edu (RS); smichael@fgcu.edu (SFM)

    Affiliation: Department of Microbiology, University of Washington, Seattle, Washington, United States of America

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  • Scott F. Michael mail

    ram@compbio.washington.edu (RS); smichael@fgcu.edu (SFM)

    Affiliation: Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, Florida, United States of America

    X
  • Published: June 22, 2010
  • DOI: 10.1371/journal.pntd.0000721

About the Authors

Joshua M. Costin, Krystal A. Fontaine, Craig R. Rees, Sharon Isern, Scott F. Michael
Department of Biological Sciences, Florida Gulf Coast University, Fort Myers, Florida, United States of America
Ekachai Jenwitheesuk, Ram Samudrala
Department of Microbiology, University of Washington, Seattle, Washington, United States of America
Shee-Mei Lok, Michael G. Rossmann
Department of Biological Sciences, Purdue University, West Lafayette, Indiana, United States of America
Elizabeth Hunsperger
Dengue Branch, Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico
Kelly A. Conrads
FortéBio, Incorporated, Menlo Park, California, United States of America

Corresponding Authors

Competing Interests

The authors acknowledge that Florida Gulf Coast University, Tulane University, and the University of Washington have submitted patent applications covering the peptides described in this manuscript.

Author Contributions

Conceived and designed the experiments: JMC EJ SI RS SFM. Performed the experiments: JMC EJ SML EH KAC KAF CRR. Analyzed the data: JMC EJ SML KAF MGR SI RS SFM. Contributed reagents/materials/analysis tools: JMC EJ SML MGR SI RS SFM. Wrote the paper: JMC SFM.