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Research Article

Mechanisms of Vascular Damage by Hemorrhagic Snake Venom Metalloproteinases: Tissue Distribution and In Situ Hydrolysis

  • Cristiani Baldo,

    Affiliation: Laboratório de Imunopatologia, Instituto Butantan, São Paulo, São Paulo, Brasil

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  • Colin Jamora,

    Affiliation: Section of Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America

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  • Norma Yamanouye,

    Affiliation: Laboratório de Farmacologia, Instituto Butantan, São Paulo, São Paulo, Brasil

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  • Telma M. Zorn,

    Affiliation: Laboratório da Biologia da Reprodução e Matriz Extracelular, Instituto de Ciências Biomédicas, USP, São Paulo, São Paulo, Brasil

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  • Ana M. Moura-da-Silva mail

    anamoura@butantan.gov.br

    Affiliation: Laboratório de Imunopatologia, Instituto Butantan, São Paulo, São Paulo, Brasil

    X
  • Published: June 29, 2010
  • DOI: 10.1371/journal.pntd.0000727

About the Authors

Cristiani Baldo, Ana M. Moura-da-Silva
Laboratório de Imunopatologia, Instituto Butantan, São Paulo, São Paulo, Brasil
Colin Jamora
Section of Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, California, United States of America
Norma Yamanouye
Laboratório de Farmacologia, Instituto Butantan, São Paulo, São Paulo, Brasil
Telma M. Zorn
Laboratório da Biologia da Reprodução e Matriz Extracelular, Instituto de Ciências Biomédicas, USP, São Paulo, São Paulo, Brasil

Corresponding Author

Email: anamoura@butantan.gov.br

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CB AMMdS. Performed the experiments: CB NY. Analyzed the data: CB CJ NY TMZ AMMdS. Contributed reagents/materials/analysis tools: CJ TMZ AMMdS. Wrote the paper: CB CJ NY TMZ AMMdS.