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Research Article

Cyclosporin A Treatment of Leishmania donovani Reveals Stage-Specific Functions of Cyclophilins in Parasite Proliferation and Viability

  • Wai-Lok Yau,

    Affiliation: G5 Virulence Parasitaire, Institut Pasteur and CNRS URA 2581, Paris, France

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  • Thierry Blisnick,

    Affiliation: Trypanosome Cell Biology Unit, Institut Pasteur and CNRS URA 2581, Paris, France

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  • Jean-François Taly,

    Affiliation: Centre de Regulacio Genomica (CRG), Universitat Pompeus Fabre, Barcelona, Spain

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  • Manuela Helmer-Citterich,

    Affiliation: Centre for Molecular Bioinformatics, Department of Biology, University of Rome Tor Vergata, Rome, Italy

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  • Cordelia Schiene-Fischer,

    Affiliation: Max-Planck Research Unit for Enzymology of Protein Folding, Halle/Saale, Germany

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  • Olivier Leclercq,

    Affiliation: G5 Virulence Parasitaire, Institut Pasteur and CNRS URA 2581, Paris, France

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  • Jing Li,

    Affiliation: Texas A&M Natural Products LINCHPIN Laboratory, Department of Chemistry, Texas A&M University, College Station, Texas, United States of America

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  • Dirk Schmidt-Arras,

    Affiliation: G5 Virulence Parasitaire, Institut Pasteur and CNRS URA 2581, Paris, France

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  • Miguel A. Morales,

    Affiliation: G5 Virulence Parasitaire, Institut Pasteur and CNRS URA 2581, Paris, France

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  • Cedric Notredame,

    Affiliation: Centre de Regulacio Genomica (CRG), Universitat Pompeus Fabre, Barcelona, Spain

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  • Daniel Romo,

    Affiliations: Texas A&M Natural Products LINCHPIN Laboratory, Department of Chemistry, Texas A&M University, College Station, Texas, United States of America, Department of Chemistry, Texas A&M University, College Station, Texas, United States of America

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  • Philippe Bastin,

    Affiliation: Trypanosome Cell Biology Unit, Institut Pasteur and CNRS URA 2581, Paris, France

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  • Gerald F. Späth mail

    gerald.spaeth@pasteur.fr

    Affiliation: G5 Virulence Parasitaire, Institut Pasteur and CNRS URA 2581, Paris, France

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  • Published: June 29, 2010
  • DOI: 10.1371/journal.pntd.0000729

About the Authors

Wai-Lok Yau, Olivier Leclercq, Dirk Schmidt-Arras, Miguel A. Morales, Gerald F. Späth
G5 Virulence Parasitaire, Institut Pasteur and CNRS URA 2581, Paris, France
Thierry Blisnick, Philippe Bastin
Trypanosome Cell Biology Unit, Institut Pasteur and CNRS URA 2581, Paris, France
Jean-François Taly, Cedric Notredame
Centre de Regulacio Genomica (CRG), Universitat Pompeus Fabre, Barcelona, Spain
Manuela Helmer-Citterich
Centre for Molecular Bioinformatics, Department of Biology, University of Rome Tor Vergata, Rome, Italy
Cordelia Schiene-Fischer
Max-Planck Research Unit for Enzymology of Protein Folding, Halle/Saale, Germany
Jing Li, Daniel Romo
Texas A&M Natural Products LINCHPIN Laboratory, Department of Chemistry, Texas A&M University, College Station, Texas, United States of America
Daniel Romo
Department of Chemistry, Texas A&M University, College Station, Texas, United States of America

Corresponding Author

Email: gerald.spaeth@pasteur.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WLY CSF GFS. Performed the experiments: WLY TB MHC CSF OL PB. Analyzed the data: WLY JFT MHC CSF DSA MAM CN GFS. Contributed reagents/materials/analysis tools: TB JFT OL JL DSA MAM CN DR PB. Wrote the paper: GFS.