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Research Article

Phase II Evaluation of Sensitivity and Specificity of PCR and NASBA Followed by Oligochromatography for Diagnosis of Human African Trypanosomiasis in Clinical Samples from D.R. Congo and Uganda

  • Enock Matovu mail,

    matovue@vetmed.mak.ac.ug

    Affiliation: Department of Veterinary Parasitology and Microbiology, Makerere University, Kampala, Uganda

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  • Claire M. Mugasa,

    Affiliations: Department of Veterinary Parasitology and Microbiology, Makerere University, Kampala, Uganda, Department of Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands

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  • Rosine Ali Ekangu,

    Affiliation: Department of Parasitology, Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo

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  • Stijn Deborggraeve,

    Affiliations: Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium, Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium

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  • George W. Lubega,

    Affiliation: Department of Veterinary Parasitology and Microbiology, Makerere University, Kampala, Uganda

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  • Thierry Laurent,

    Affiliation: Coris BioConcept, Gembloux, Belgium

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  • Gerard J. Schoone,

    Affiliation: Department of Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands

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  • Henk D. Schallig,

    Affiliation: Department of Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands

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  • Philippe Büscher

    Affiliation: Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium

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  • Published: July 06, 2010
  • DOI: 10.1371/journal.pntd.0000737
  • Featured in PLOS Collections

About the Authors

Enock Matovu, Claire M. Mugasa, George W. Lubega
Department of Veterinary Parasitology and Microbiology, Makerere University, Kampala, Uganda
Claire M. Mugasa, Gerard J. Schoone, Henk D. Schallig
Department of Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands
Rosine Ali Ekangu
Department of Parasitology, Institut National de Recherche Biomédicale (INRB), Kinshasa, Democratic Republic of the Congo
Stijn Deborggraeve, Philippe Büscher
Department of Parasitology, Institute of Tropical Medicine, Antwerp, Belgium
Stijn Deborggraeve
Rega Institute, Katholieke Universiteit Leuven, Leuven, Belgium
Thierry Laurent
Coris BioConcept, Gembloux, Belgium

Corresponding Author

Email: matovue@vetmed.mak.ac.ug

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EM GWL GJS HDS PB. Performed the experiments: EM CMM RAE SD TL. Analyzed the data: EM CMM RAE SD GWL TL PB. Contributed reagents/materials/analysis tools: GWL TL GJS HDS PB. Wrote the paper: EM CMM RAE SD GJS HDS PB.