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Research Article

The First Human Epitope Map of the Alphaviral E1 and E2 Proteins Reveals a New E2 Epitope with Significant Virus Neutralizing Activity

  • Ann R. Hunt mail,

    Ann.Hunt@colostate.edu

    Affiliation: Microbiology, Immunology and Pathology Department, Colorado State University, Fort Collins, Colorado, United States of America

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  • Shana Frederickson,

    Affiliation: Alexion Antibody Technologies, San Diego, California, United States of America

    Current address: Life Technologies, Carlsbad, California, United States of America

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  • Toshiaki Maruyama,

    Affiliation: Alexion Antibody Technologies, San Diego, California, United States of America

    Current address: Calmune Corporation, San Diego, California, United States of America

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  • John T. Roehrig,

    Affiliation: Division of Vector-Borne Infectious Diseases, Centers for Disease Control, Fort Collins, Colorado, United States of America

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  • Carol D. Blair

    Affiliation: Microbiology, Immunology and Pathology Department, Colorado State University, Fort Collins, Colorado, United States of America

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  • Published: July 13, 2010
  • DOI: 10.1371/journal.pntd.0000739

About the Authors

Ann R. Hunt, Carol D. Blair
Microbiology, Immunology and Pathology Department, Colorado State University, Fort Collins, Colorado, United States of America
Shana Frederickson, Toshiaki Maruyama
Alexion Antibody Technologies, San Diego, California, United States of America
John T. Roehrig
Division of Vector-Borne Infectious Diseases, Centers for Disease Control, Fort Collins, Colorado, United States of America

Corresponding Author

Email: Ann.Hunt@colostate.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ARH SF TM JTR. Performed the experiments: ARH TM. Analyzed the data: ARH SF TM JTR CDB. Contributed reagents/materials/analysis tools: SF JTR CDB. Wrote the paper: ARH JTR CDB.