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Research Article

High Rates of Homologous Recombination in the Mite Endosymbiont and Opportunistic Human Pathogen Orientia tsutsugamushi

  • Piengchan Sonthayanon mail,

    piengchan@tropmedres.ac

    Affiliations: Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Sharon J. Peacock,

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Department of Medicine, University of Cambridge, Cambridge, United Kingdom

    X
  • Wirongrong Chierakul,

    Affiliations: Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

    X
  • Vanaporn Wuthiekanun,

    Affiliation: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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  • Stuart D. Blacksell,

    Affiliation: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

    X
  • Mathew T. G. Holden,

    Affiliation: The Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Stephen D. Bentley,

    Affiliation: The Wellcome Trust Sanger Institute, Hinxton, United Kingdom

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  • Edward J. Feil,

    Affiliation: Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom

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  • Nicholas P. J. Day

    Affiliations: Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

    X
  • Published: July 20, 2010
  • DOI: 10.1371/journal.pntd.0000752

About the Authors

Piengchan Sonthayanon, Wirongrong Chierakul
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Piengchan Sonthayanon, Sharon J. Peacock, Wirongrong Chierakul, Vanaporn Wuthiekanun, Stuart D. Blacksell, Nicholas P. J. Day
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Sharon J. Peacock
Department of Medicine, University of Cambridge, Cambridge, United Kingdom
Mathew T. G. Holden, Stephen D. Bentley
The Wellcome Trust Sanger Institute, Hinxton, United Kingdom
Edward J. Feil
Department of Biology and Biochemistry, University of Bath, Bath, United Kingdom
Nicholas P. J. Day
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

Corresponding Author

Email: piengchan@tropmedres.ac

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PS SJP NPD. Performed the experiments: PS WC VW SDB MTGH SDB. Analyzed the data: PS SJP MTGH SDB EJF NPD. Contributed reagents/materials/analysis tools: PS SJP WC VW SDB MTGH SDB EJF. Wrote the paper: PS SJP EJF NPD.